Universality of clonal dynamics poses fundamental limits to identify stem cell self-renewal strategies.

ELife
Cristina Parigini, Philip Greulich

Abstract

How adult stem cells maintain self-renewing tissues is commonly assessed by analysing clonal data from in vivo cell lineage-tracing assays. To identify strategies of stem cell self-renewal requires that different models of stem cell fate choice predict sufficiently different clonal statistics. Here, we show that models of cell fate choice can, in homeostatic tissues, be categorized by exactly two 'universality classes', whereby models of the same class predict, under asymptotic conditions, the same clonal statistics. Those classes relate to generalizations of the canonical asymmetric vs. symmetric stem cell self-renewal strategies and are distinguished by a conservation law. This poses both challenges and opportunities to identify stem cell self-renewal strategies: while under asymptotic conditions, self-renewal models of the same universality class cannot be distinguished by clonal data only, models of different classes can be distinguished by simple means.

References

Jun 3, 1998·Methods : a Companion to Methods in Enzymology·B Sauer
Feb 26, 2000·Science·F M Watt, B L Hogan
Mar 3, 2007·Nature·Elizabeth ClaytonPhilip H Jones
Aug 12, 2009·Journal of Pain & Palliative Care Pharmacotherapy·UNKNOWN National Institute of Neurological Disorders, National Institutes of Health
Aug 5, 2010·Cell Stem Cell·Allon M KleinBenjamin D Simons
Oct 12, 2010·Science·Carlos Lopez-GarciaDouglas J Winton
Jun 15, 2011·Cell·Benjamin D Simons, Hans Clevers
Jul 14, 2011·Development·Allon M Klein, Benjamin D Simons
Jul 27, 2011·Experimental Cell Research·Benjamin D Simons, Hans Clevers
Nov 29, 2011·Cell·Mikael J Pittet, Ralph Weissleder
Jan 24, 2012·Cell·Kai Kretzschmar, Fiona M Watt
Jul 19, 2013·Nature Reviews. Molecular Cell Biology·Cédric Blanpain, Benjamin D Simons
Oct 14, 2014·Trends in Cell Biology·Paul W TettehHans Clevers
May 11, 2015·Cell Stem Cell·Giacomo Donati, Fiona M Watt
May 28, 2016·Science·Panteleimon RompolasValentina Greco
Jun 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Philip Greulich, Benjamin D Simons
Feb 22, 2018·Proceedings of the National Academy of Sciences of the United States of America·Caleb WeinrebAllon M Klein
May 8, 2019·Methods in Molecular Biology·Philip Greulich
Jan 7, 2020·Royal Society Open Science·Philip GreulichRubén J Sánchez-García

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