PMID: 8604918Dec 1, 1995Paper

University of Wisconsin cerebroplegia in a piglet survival model of circulatory arrest

The Annals of Thoracic Surgery
J ForbessR A Jonas

Abstract

Previous acute studies in immature piglets at our institution have demonstrated improved recovery of cerebral blood flow, intracellular pH, and high-energy phosphates with the administration of multidose University of Wisconsin solution as cerebroplegia during a period of deep hypothermic circulatory arrest (HCA). In an effort to define further the clinical applicability of this technique, we have developed a survival model of swine cardiopulmonary bypass (CPB) and HCA. 12 Yorkshire pigs (age 4 to 5 weeks) were placed on CPB via the right femoral artery and right atrium. Animals were cooled to a rectal temperature of 15 degrees C and submitted to 90 minutes of HCA. Group UW (n = 6) received a single infusion of 50 mL/kg of 4 degrees C University of Wisconsin solution delivered antegrade to the cerebral circulation. The control group (n = 6) received no intervention. Animals were reperfused, rewarmed to 35 degrees C, and weaned from CPB. Neurologic assessments using neurologic deficit scoring (0 = normal, 500 = brain death) and overall performance categories (1 = normal, 5 = brain death) were performed at 24-hour intervals for 5 days. On the 5th postoperative day all brains were perfusion-fixed and examined for histologic eviden...Continue Reading

References

Oct 1, 1992·The Annals of Thoracic Surgery·C K MezrowR B Griepp
Jun 1, 1991·The Annals of Thoracic Surgery·M D CrittendenJ A Swain
Jan 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y LeonovS W Stezoski
Apr 1, 1988·Transplantation·F O Belzer, J H Southard
Aug 15, 1966·Experientia·A W Brown, J B Brierley
Jan 1, 1994·The Annals of Thoracic Surgery·J R MaultR M Ungerleider
Apr 1, 1963·Annals of Surgery·L H EdmundsR B Brown

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Citations

Feb 10, 1998·The Annals of Thoracic Surgery·T Shin'okaR A Jonas
Dec 23, 2003·The Journal of Thoracic and Cardiovascular Surgery·Bradley S AllenZhongtou Tan
Jun 3, 2004·The Journal of Thoracic and Cardiovascular Surgery·Vesa AnttilaRichard A Jonas
Sep 27, 2006·The Journal of Thoracic and Cardiovascular Surgery·Vesa AnttilaRichard A Jonas
Nov 7, 1998·The Journal of Thoracic and Cardiovascular Surgery·D Shum-TimR A Jonas
May 27, 1999·The Journal of Thoracic and Cardiovascular Surgery·G NollertR A Jonas
May 27, 1999·The Journal of Thoracic and Cardiovascular Surgery·T Shin'okaR A Jonas
Aug 4, 2005·The Journal of Thoracic and Cardiovascular Surgery·Ikuo HaginoRichard A Jonas
Mar 27, 2003·The Journal of Thoracic and Cardiovascular Surgery·Bradley S AllenLouis J Ignarro
Nov 26, 2010·The Annals of Thoracic Surgery·Toru OkamuraRichard A Jonas
May 8, 2002·Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual·Richard A Jonas
Sep 27, 2005·The Annals of Thoracic Surgery·Vesa AnttilaRichard A Jonas
Aug 2, 2001·The Journal of Thoracic and Cardiovascular Surgery·T SakamotoR A Jonas
Jul 30, 2004·The Journal of Thoracic and Cardiovascular Surgery·Takahiko SakamotoRichard A Jonas
May 26, 2009·The Journal of Thoracic and Cardiovascular Surgery·Yusuke IwataRichard A Jonas
Dec 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·T Shin'okaA du Plessis

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