Unknown primary carcinoma in the Netherlands: decrease in incidence and survival times remain poor between 2000 and 2012

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
C Schroten-LoefV E P P Lemmens

Abstract

Unknown primary tumour (UPT) is the term applied to metastatic cancer, the origin of which remains unidentified. Since cancer treatment is primarily based on the tumour site of origin, treatment of UPT patients is challenging. The number of reports on incidence, treatment and survival of UPT is limited. We hereby report data on patients (2000-2012) with UPT in the Netherlands. The age-standardised rate (ASR) of 'other and unspecified' malignancies in the Netherlands was compared with other European countries. Patients diagnosed with UPT between 2000 and 2012 were selected from the Netherlands Cancer Registry (NCR) to calculate incidence rates. Patient characteristics, treatment and survival rates were assessed. The ASR of 'other and unspecified' malignancies in the Netherlands did not differ from the European average ASRs (2008-2012). A total of 29,784 patients with an unknown primary tumour were selected from the NCR (2000-2012). The incidence decreased from 14 per 100,000 person years (European standardised rate) in 2000 to 7.0 in 2012. The most common metastatic sites were liver, lymph nodes, bone and lung (42%, 22%, 16% and 14%, respectively), and approximately two-thirds of patients were diagnosed with metastases at a sing...Continue Reading

Citations

May 31, 2019·International Journal of Cancer. Journal International Du Cancer·Nicholas PavlidisJulie Smith-Gagen
Oct 7, 2020·International Journal of Cancer. Journal International Du Cancer·Karlijn E P E HermansLeo J Schouten
Dec 9, 2020·BMJ : British Medical Journal·Michael S Lee, Hanna K Sanoff
Jan 31, 2021·Clinical & Experimental Metastasis·L MeijerC Loef
Jun 30, 2019·Cancer Epidemiology·Elie Rassy, Nicholas Pavlidis
May 13, 2021·European Journal of Cancer Care·Caroline Loef, Matthias A W Merkx
May 16, 2021·International Journal of Cancer. Journal International Du Cancer·Niek HugenIris D Nagtegaal
Jun 23, 2021·European Journal of Nutrition·Karlijn E P E HermansLeo J Schouten
Jul 24, 2021·Military Medicine·Julie A BytnarKangmin Zhu
Jul 6, 2021·European Journal of Cancer Care·Alexander L R GrewcockLeo J Schouten

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