Unlearning tinnitus-related cerebral synchrony with acoustic coordinated reset stimulation: theoretical concept and modelling

Biological cybernetics
Peter A Tass, Oleksandr V Popovych

Abstract

Tinnitus is a deafferentation-induced phantom phenomenon characterized by abnormal cerebral synchrony and connectivity. Computationally, we show that desynchronizing acoustic coordinated reset (CR) stimulation can effectively counteract both up-regulated synchrony and connectivity. CR stimulation has initially been developed for the application to electrical deep brain stimulation. We here adapt this approach to non-invasive, acoustic CR stimulation. For this, we use the tonotopic organization of the central auditory system and replace electrical stimulation bursts applied to different brain sites by acoustically delivered tones of different pitch. Based on our simulations, we propose non-invasive acoustic CR stimulation as a possible novel therapy for tinnitus.

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Citations

Jan 1, 2014·Hearing Research·Roland Schaette
Feb 13, 2016·Nature Reviews. Neurology·Susan E ShoreBerthold Langguth
Nov 30, 2012·Journal of Neurochemistry·Vladimir ParpuraRussell J Andrews
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Aug 3, 2013·Human Brain Mapping·Ilya AdamchicPeter Alexander Tass
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Sep 10, 2013·Hearing Research·Farhait KianiRoland Schaette
Apr 16, 2015·Frontiers in Systems Neuroscience·Magteld Zeitler, Peter A Tass
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Oct 14, 2014·Frontiers in Neuroscience·Ilya AdamchicPeter A Tass
Dec 17, 2014·Frontiers in Computational Neuroscience·Martin EbertPeter A Tass
Jun 7, 2014·Frontiers in Neuroscience·Joshua R Gold, Victoria M Bajo
Jun 1, 2016·Frontiers in Computational Neuroscience·Magteld Zeitler, Peter A Tass
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Jan 30, 2021·Physical Review Letters·Rico BernerSerhiy Yanchuk
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