Unlocking Human Brain Metabolism by Genome-Scale and Multiomics Metabolic Models: Relevance for Neurology Research, Health, and Disease

Omics : a Journal of Integrative Biology
Mustafa Sertbaş, Kutlu Ulgen

Abstract

Neurology research and clinical practice are transforming toward postgenomics integrative biology. One such example is the study of human brain metabolism that is highly sophisticated due to reactions occurring in and between the astrocytes and neurons. Because of the inherent difficulty of performing experimental studies in human brain, metabolic network modeling has grown in importance to decipher the contribution of brain metabolite kinetics to human health and disease. Multiomics system science-driven metabolic models, using genome-scale and transcriptomics Big Data, offer the promise of new insights on metabolic networks in human brain. Added to this, the availability of omics technologies in both developed and developing world, neurology research, and clinical practice ought to be repositioned with a view to systems medicine. In this expert analysis, we present a critical and in-depth overview of the basic tenets of human brain metabolism, together with the most recent metabolic modeling strategies and computational studies of brain in health and neurological diseases. Human genome-scale metabolic models developed in a both global and brain-specific manner and multiomics synthesis of knowledge are highlighted in particula...Continue Reading

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Citations

Jun 13, 2020·Critical Reviews in Toxicology·Deepika DeepikaVikas Kumar
Apr 24, 2020·Nature Reviews. Neurology·Joan MontanerAlejandro Bustamante
Aug 28, 2020·Frontiers in Neuroinformatics·Janneth GonzálezCynthia Martín-Jiménez
Oct 17, 2020·Omics : a Journal of Integrative Biology·Nguyen Hoang AnhNguyen Phuoc Long
Jul 21, 2021·ACS Chemical Neuroscience·Siwei ChenAmal Alachkar

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Software Mentioned

GIMME
MADE
Recon1
Recon3D
SWISS
Recon2
GeneCards
PROT
Ensembl
iMS570

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