Unlocking the direct photocatalytic difluoromethylation of C[double bond, length as m-dash]N bonds.

Chemical Communications : Chem Comm
Alberto F Garrido-CastroJosé Alemán

Abstract

The current study presents a direct CF2H radical addition to C[double bond, length as m-dash]N bonds predicated on the photocatalytic activation of commercially available zinc difluoromethanesulfinate. The mild conditions in place lead to impressive structural diversity, as quinoxalinones and dibenzazepines, among others, are successfully functionalized.

References

Mar 1, 2003·Journal of Natural Products·Xiao-Hua XuChui-Hua Kong
Apr 1, 1994·Natural Product Reports·D B Harper, D O'Hagan
Sep 29, 2007·Science·Klaus MüllerFrançois Diederich
Jan 17, 2008·Chemical Society Reviews·Sophie PurserVéronique Gouverneur
Jun 24, 2008·Journal of Medicinal Chemistry·William K Hagmann
Dec 22, 2009·Chemical Communications : Chem Comm·Jinbo HuFei Wang
Mar 19, 2011·Journal of Medicinal Chemistry·Nicholas A Meanwell
Apr 5, 2011·Chemical Reviews·Olesya A Tomashenko, Vladimir V Grushin
Jan 11, 2012·Journal of the American Chemical Society·Yuta FujiwaraPhil S Baran
Feb 16, 2012·Chemical Communications : Chem Comm·Charlotte Hollingworth, Véronique Gouverneur
Aug 15, 2012·Angewandte Chemie·Armido Studer
May 4, 2013·Nature Protocols·Fionn O'HaraPhil S Baran
Jul 23, 2013·Angewandte Chemie·Theresa LiangTobias Ritter
Dec 17, 2015·Chemical Science·Megan A Cismesia, Tehshik P Yoon
Aug 27, 2016·Accounts of Chemical Research·Takashi Koike, Munetaka Akita
Oct 19, 2016·Accounts of Chemical Research·Tanmay ChatterjeeEun Jin Cho
Jan 5, 2017·Journal of Medicinal Chemistry·Yossi ZafraniSigal Saphier
Jun 21, 2017·Chemistry : a European Journal·Damian E YerienAl Postigo
Nov 2, 2017·Mini Reviews in Medicinal Chemistry·Leilei ShiXun Li
May 16, 2019·Organic & Biomolecular Chemistry·Takashi Koike, Munetaka Akita
Nov 5, 2019·Advanced Synthesis & Catalysis·Agostinho LemosAndré Luxen

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Citations

Sep 24, 2020·Chemical Communications : Chem Comm·Hai-Yan SuFeng-Ling Qing
Sep 25, 2020·Chemical Communications : Chem Comm·Thomas Rigotti, José Alemán
Jun 3, 2021·Chemical Society Reviews·Jeroen B I SapVéronique Gouverneur
Aug 19, 2021·The Journal of Organic Chemistry·Youjung ByunIn Su Kim

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