Unlocking the potential of the human genome with RNA interference

Nature
Gregory J Hannon, John J Rossi

Abstract

The discovery of RNA interference (RNAi) may well be one of the transforming events in biology in the past decade. RNAi can result in gene silencing or even in the expulsion of sequences from the genome. Harnessed as an experimental tool, RNAi has revolutionized approaches to decoding gene function. It also has the potential to be exploited therapeutically, and clinical trials to test this possibility are already being planned.

References

May 1, 1997·Biochemical Society Transactions·B R Williams
Dec 9, 2000·Science·K J BlightC M Rice
Jan 11, 2001·Journal of Virology·T PietschmannR Bartenschlager
May 3, 2001·Nature·J Ziauddin, D M Sabatini
Dec 12, 2001·Molecular Therapy : the Journal of the American Society of Gene Therapy·B Dropulic
Feb 28, 2002·Current Biology : CB·Eric G Moss
Apr 5, 2002·Trends in Genetics : TIG·Amy E Pasquinelli
Jun 4, 2002·Nature Medicine·Carl D NovinaPhillip A Sharp
Jun 28, 2002·Nature·Jean-Marc JacqueMario Stevenson
Jul 5, 2002·Nature·Anton P McCaffreyMark A Kay
Jul 12, 2002·Nature·Gregory J Hannon
Jul 23, 2002·Nature Biotechnology·Ki-Young LeeShuo Lin
Jul 30, 2002·Nature Genetics·David L LewisHans Herweijer
Aug 6, 2002·Experimental Hematology·Chiara Dell'AgnolaFrancesco Bertolini
Sep 21, 2002·Cancer Cell·Thijn R BrummelkampReuven Agami
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·John CapodiciDrew Weissman
Oct 24, 2002·Blood·Michaela ScherrMatthias Eder
Dec 3, 2002·FEBS Letters·Hidetoshi HasuwaMasaru Okabe
Jan 9, 2003·Proceedings of the National Academy of Sciences of the United States of America·Xiao-Feng QinDavid Baltimore
Jan 9, 2003·Proceedings of the National Academy of Sciences of the United States of America·Glenn RandallCharles M Rice
Jan 22, 2003·Nature Structural Biology·Michelle A CarmellThomas A Rosenquist
Jan 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Gustavo TiscorniaInder M Verma
Feb 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Sharookh B KapadiaFrancis V Chisari
Feb 13, 2003·Nature Medicine·Erwei SongJudy Lieberman
Feb 21, 2003·Proceedings of the National Academy of Sciences of the United States of America·Joyce A WilsonChristopher D Richardson
Mar 26, 2003·Journal of Molecular Biology·Dag R SørensenMouldy Sioud
May 13, 2003·Nature Biotechnology·Anton P McCaffreyMark A Kay
May 20, 2003·Nature Biotechnology·Aimee L JacksonPeter S Linsley

❮ Previous
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Citations

Aug 13, 2011·Functional & Integrative Genomics·Sadegh Azimzadeh Jamalkandi, Ali Masoudi-Nejad
May 6, 2011·Biotechnology Letters·Xing LiHaibin Xia
Jan 3, 2006·Cellular and Molecular Neurobiology·Victor M MillerPedro Gonzalez-Alegre
Mar 23, 2011·Pharmaceutical Research·Ji Hoon JeongSun Hwa Kim
Dec 18, 2012·Pharmaceutical Research·Mengjie RuiYuhong Xu
Feb 19, 2009·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Ming CaiChangxue Cai
Oct 13, 2009·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Shi LuLijun Wang
Jul 4, 2012·Journal of Biosciences·Bidisha NandyPrabal K Maiti
Apr 14, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shamima YeasminKohji Miyazaki
Jun 9, 2005·Fish & Shellfish Immunology·Uwe FischerTeruyuki Nakanishi
Jun 14, 2005·Trends in Biochemical Sciences·David Baulcombe
Nov 8, 2011·Biomacromolecules·Siew Ching KowVolga Bulmus
Oct 1, 2009·Journal of the American Chemical Society·Deepak KumarYohei Yokobayashi
Aug 2, 2006·Molecular BioSystems·Yeliz UtkuKent Kirshenbaum
Dec 7, 2007·The Journal of Clinical Investigation·Dirk Grimm, Mark A Kay
May 30, 2006·BMC Bioinformatics·Peilin JiaYixue Li
Dec 2, 2006·BMC Bioinformatics·Jean-Philippe VertYves Vandenbrouck
Dec 22, 2010·BMC Genomics·Liangjiang WangJack Y Yang
Apr 21, 2007·BMC Genomics·Jean-François RualGuillaume Achaz
Nov 2, 2007·BMC Genomics·Stephanie BechtelIngo Schupp
Nov 6, 2008·BMC Genomics·Todd WylieMakedonka Mitreva
Aug 9, 2011·BMC Molecular Biology·Glen J McIntyreGregory C Fanning
Feb 1, 2006·BMC Neuroscience·Anne L CahillAaron P Fox
Jan 7, 2006·BMC Biotechnology·Glen J McIntyre, Gregory C Fanning
Apr 19, 2011·Genetic Vaccines and Therapy·Glen J McIntyreGregory C Fanning
Feb 18, 2010·Theoretical Biology & Medical Modelling·Misaki Wayengera
Nov 13, 2007·Retrovirology·Yuki NaitoYutaka Takebe
Jun 6, 2009·Retrovirology·Glen John McIntyreTanya Lynn Applegate
May 23, 2006·AIDS Research and Therapy·Alessandro MichienziJohn J Rossi
Jan 14, 2011·AIDS Research and Therapy·Glen J McIntyreTanya L Applegate

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