Unloosing the Gordian knot of peroxisome formation.

Current Opinion in Cell Biology
Joseph L Costello, M Schrader

Abstract

Peroxisome biogenesis is governed by molecular machineries, which are either unique to peroxisomes or are partially shared with mitochondria. As peroxisomes have important protective functions in the cell, modulation of their number is important for human health and disease. Significant progress has been made towards our understanding of the mechanisms of peroxisome formation, revealing a remarkable plasticity of the peroxisome biogenesis pathway. Here we discuss most recent findings with particular focus on peroxisome formation in mammalian cells.

Citations

Mar 14, 2019·Journal of Inherited Metabolic Disease·Michael SchraderMarkus Islinger
Sep 17, 2018·Histochemistry and Cell Biology·Markus IslingerMichael Schrader
Jun 15, 2019·Contact·Alexa BishopMichael Schrader
Mar 27, 2020·The Journal of Cell Biology·Fred D MastJohn D Aitchison
Nov 4, 2020·Cellular and Molecular Life Sciences : CMLS·Christian Covill-CookeJosef T Kittler

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Methods Mentioned

BETA
ubiquitination
GTPase
protein exchange

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