Unmasking local activity within local field potentials (LFPs) by removing distal electrical signals using independent component analysis

NeuroImage
Nathan W Whitmore, Shih-Chieh Lin

Abstract

Local field potentials (LFPs) are commonly thought to reflect the aggregate dynamics in local neural circuits around recording electrodes. However, we show that when LFPs are recorded in awake behaving animals against a distal reference on the skull as commonly practiced, LFPs are significantly contaminated by non-local and non-neural sources arising from the reference electrode and from movement-related noise. In a data set with simultaneously recorded LFPs and electroencephalograms (EEGs) across multiple brain regions while rats perform an auditory oddball task, we used independent component analysis (ICA) to identify signals arising from electrical reference and from volume-conducted noise based on their distributed spatial pattern across multiple electrodes and distinct power spectral features. These sources of distal electrical signals collectively accounted for 23-77% of total variance in unprocessed LFPs, as well as most of the gamma oscillation responses to the target stimulus in EEGs. Gamma oscillation power was concentrated in volume-conducted noise and was tightly coupled with the onset of licking behavior, suggesting a likely origin of muscle activity associated with body movement or orofacial movement. The removal ...Continue Reading

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Citations

Feb 12, 2019·PLoS Computational Biology·Nicholas RogersVikash Gilja
Jul 7, 2018·Computational and Mathematical Methods in Medicine·Weifeng LiYun Ge
Jan 11, 2017·Biomedical Engineering Letters·Liu XinyuShi Li
Apr 4, 2019·Cerebral Cortex·Daniel TorresOscar Herreras
Jul 13, 2018·Frontiers in Neuroscience·Gonzalo Martín-VázquezTomoki Fukai
Jan 15, 2021·Biomedical Physics & Engineering Express·Juan Pablo MarcoletaTheodor Doll
Nov 27, 2020·Journal of Neural Engineering·Nur AhmadiChristos-Savvas Bouganis
Jan 22, 2021·Journal of Neural Engineering·Nur AhmadiChristos-Savvas Bouganis
Dec 4, 2016·Journal of Physiology, Paris·Jayakrishnan NairGregor Rainer
Apr 21, 2021·Applied Psychophysiology and Biofeedback·Muhammad A HasanMatthew Fraser

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Software Mentioned

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