Unmasking of type III hyperlipoproteinemia by hypothyroidism: a dramatic illustration of altered lipoprotein metabolism in a postpartum woman.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Ravi RetnakaranJeannette Goguen

Abstract

To illustrate the potential abnormalities in lipoprotein metabolism associated with type III hyper-lipoproteinemia and the modulation of their clinical expression by thyroid hormone and estrogenic status. An illustrative case, with associated clinical and laboratory data, is presented, and relevant clinical and pathophysiologic studies from the literature are reviewed. A 35-year-old woman, at 7 months after delivery of her first child, presented to her family physician with a complaint of painful eruptions on the palms of her hands. On evaluation, she was found to have new hypothyroidism and severe hypertriglyceridemia (>1,569 mg/dL). Thyroxine replacement was initiated, and she was referred to the lipid clinic. When seen in the lipid clinic shortly thereafter, her triglyceride level had normalized, but her low-density lipoprotein (LDL) fraction was strikingly elevated (representing a combination of elevated intermediate-density lipoprotein and LDL cholesterol). On physical examination, palmar xanthomas were noted, suggestive of type III hyperlipoproteinemia. This diagnosis was further supported by homozygosity at the apolipoprotein E (apo E) gene locus for the apo E2 allele implicated in this condition. Ultimately, with attain...Continue Reading

References

Dec 1, 1987·Postgraduate Medical Journal·D CarrP R Turner
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G R ThompsonN B Myant
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·C EhnholmJ L Witztum
Oct 1, 1982·European Journal of Clinical Investigation·S ValdemarssonP Nilsson-Ehle
Jan 6, 2000·Postgraduate Medical Journal·M A CrookK Marshall
Jan 22, 2000·Postgraduate Medical Journal·A S Kashyap, S Kashyap

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Citations

Sep 11, 2012·The Journal of Clinical Endocrinology and Metabolism·Lars BerglundUNKNOWN Endocrine society
Jan 11, 2014·Critical Reviews in Clinical Laboratory Sciences·A D MaraisD J Blom
Jan 19, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Charlotte KoopalFrank L J Visseren

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