Unmedicated, remitted patients with major depression have decreased serum immunoglobulin A

Neuroscience Letters
Philip W GoldMitchel A Kling

Abstract

Patents with major depression have evidence of a proinflammatory state with consistent elevations in acute phase proteins and in the levels of inflammatory mediators such as interleukin-6 and tumor necrosis factor-α. We report here a study of the serum levels of immunoglobulin A (IgA) in medication-free patients with major depression in the remitted state (ruMDD). Selective IgA deficiency is the most common form of immunoglobulin abnormality, and is often associated with a higher than expected incidence of proinflammatory and autoimmune phenomena. We measured serum IgG, IgM, and IgA in 28 ruMDD patients and 27 healthy subjects (Ctrl) at 0 (pretreatment), 7, and 24h following sham depletion and tryptophan (TrpD) depletion conducted at least 8 days apart under balanced, randomized, blinded conditions. Immunoglobulins were measured by automated immunonephelometry. Data were analyzed by repeated measures ANOVA with diagnosis as a fixed effect and drug (TrpD vs. sham), and time as repeated measures factors. Serum IgA was consistently lower in ruMDD patients vs. Ctrl at all time points examined (p<0.04 for main effect of diagnosis). Serum IgG and IgM levels did not show significant differences by diagnosis. Medication-free patients w...Continue Reading

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Citations

Mar 2, 2013·The Journal of Sexual Medicine·Tierney Lorenz, Sari van Anders
Oct 23, 2015·Psychoneuroendocrinology·Faustina M DelanyNicholas B Allen
Oct 4, 2016·Journal of Psychiatric Research·Man K ChanSabine Bahn
Jan 13, 2015·Immunology·Nataliia BakuninaPatricia A Zunszain

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