Unmet Needs in High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms (WHO G3)

Neuroendocrinology
Halfdan SorbyeENETS 2016 Munich Advisory Board Participants

Abstract

Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are classified based on morphology and graded based on their proliferation rate as either well-differentiated low-grade (G1 to G2) neuroendocrine tumors (NET) or poorly differentiated high-grade (G3) neuroendocrine carcinomas (NEC). Recently, a new subgroup of well-differentiated high-grade pancreatic tumors (NET G3) has been defined. The GEP NEN G3 group consisting of both NEC and NET G3 has recently been shown to be a quite heterogeneous patient group concerning prognosis and treatment benefit, depending on factors such as the primary tumor site, differentiation, proliferation rate, and molecular alterations. In this review we discuss the existing data on diagnostics, treatment, and biomarkers in this patient group, the unmet needs, and the future perspectives.

Citations

Jun 17, 2020·Frontiers in Oncology·Martine BocchiniMassimiliano Mazza
Aug 26, 2020·Nature Reviews. Endocrinology·Guido Rindi, Bertram Wiedenmann
Sep 29, 2019·World Journal of Gastroenterology : WJG·Zhi-Jie WangQian Liu
Aug 21, 2019·Current Treatment Options in Oncology·Mohamad Bassam Sonbol, Thorvardur R Halfdanarson
Feb 9, 2021·Clinical Colorectal Cancer·Benjamin E UeberrothM Bassam Sonbol
Mar 1, 2021·Current Treatment Options in Oncology·Chiara BorgaMatteo Fassan
Apr 16, 2021·Current Oncology Reports·Konstantin BräutigamAurel Perren
Aug 24, 2019·Biochimica Et Biophysica Acta. Reviews on Cancer·Wu-Hu ZhangLiang Liu
May 1, 2021·Cancers·Anna La SalviaRocío Garcia-Carbonero
May 4, 2021·Pancreas·Jennifer J GileThorvardur R Halfdanarson
Jul 24, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Zhijie WangQian Liu

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