PMID: 9174474Jun 1, 1997Paper

Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements

The American Journal of Clinical Nutrition
P KellyJ M Scott

Abstract

Periconceptual consumption of folic acid has been shown to decrease the incidence of neural tube defects. The strategy of universal fortification of staple foodstuffs with folic acid presents the possibility of life-long exposure to unmetabolized folic acid. Chief among the risks of exposure to folic acid in the circulation is that of masking the diagnosis of cobalamin deficiency in pernicious anemia and the progression of neurologic disease. Other effects are unknown. For instance, the effect of in vivo chronic exposure of adult and fetal cells to the synthetic form of the vitamin has never been investigated at the population level. This study examined the acute appearance of unmetabolized folic acid in serum in response to the consumption of some fortified foodstuffs by young and elderly volunteers. Subjects on a 5-d regimen of fortified ready-to-eat-cereal and bread in addition to their normal diet had a threshold intake of 266 micrograms folic acid per meal at which unaltered folic acid appeared in the serum. Subjects given folic acid in either isotonic saline, milk, or white bread also had a threshold > 200 micrograms. From patterns of food consumption in the United States, the implementation of flour fortification at 1.4 ...Continue Reading

Citations

Jan 30, 1999·The American Journal of Clinical Nutrition·I A BrouwerR P Steegers-Theunissen
Feb 28, 2004·The Journal of Nutrition·Kristina PentievaJohn M Scott
Oct 7, 2004·The Journal of Nutrition·Wolfgang Sichert-Hellert, Mathilde Kersting
Sep 28, 2004·The American Journal of Clinical Nutrition·Mary P Hannon-FletcherHelene McNulty
Aug 10, 2004·Nutrition Reviews·Elizabeth A Yetley, Jeanne I Rader
Mar 22, 2006·The Journal of Nutrition·Lindsay H Allen
Oct 21, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Mark D Lucock
Feb 14, 2007·Molecular Nutrition & Food Research·Young-In Kim
Jul 9, 2009·International Journal of Cancer. Journal International Du Cancer·Joanne KotsopoulosShelley S Tworoger
Mar 12, 2010·The American Journal of Clinical Nutrition·Marie A Caudill
Jun 25, 2010·The American Journal of Clinical Nutrition·Veronica E OhrvikCornelia M Witthöft
Mar 23, 2012·The Journal of Nutrition·Breanne G SwayneAmanda J MacFarlane
Apr 25, 2012·Obstetrics and Gynecology International·Carolyn TamGideon Koren
Feb 16, 2012·Antioxidants & Redox Signaling·Anna LyYoung-In Kim
Nov 17, 2012·Advances in Nutrition·Martha Savaria Morris
Sep 7, 2013·Critical Reviews in Food Science and Nutrition·Anja OsterhuesKarin B Michels
Feb 13, 2015·Critical Reviews in Food Science and Nutrition·Jing HuNadine R Sahyoun
Jan 13, 2015·Preventive Nutrition and Food Science·Jeong-Hwa ChoiMark Lucock
Aug 14, 2015·The American Journal of Clinical Nutrition·Lesley PlumptreYoung-In Kim
Oct 13, 2016·European Journal of Clinical Nutrition·K R Patel, A Sobczyńska-Malefora
Sep 20, 2018·Journal of Clinical Pathology·Agata Sobczyńska-Malefora, Dominic J Harrington
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Jun 11, 2002·Annual Review of Nutrition·Jesse F Gregory, Eoin P Quinlivan
Aug 24, 2004·The American Journal of Clinical Nutrition·Øyvind BleieOttar Nygård
Jun 2, 2005·European Journal of Clinical Nutrition·R J de JongJ J M Castenmiller
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