Unmodified hydrated С60 fullerene molecules exhibit antioxidant properties, prevent damage to DNA and proteins induced by reactive oxygen species and protect mice against injuries caused by radiation-induced oxidative stress

Nanomedicine : Nanotechnology, Biology, and Medicine
S V GudkovAndrey V Zvyagin

Abstract

Unmodified hydrated С60 fullerene molecules (C60UHFM) were shown to reduce the formation ROS in water and 8-oxoguanine in DNA upon ionizing radiation impact. C60UHFM efficiently eliminate long-lived protein radicals arising after irradiation. In irradiated mice C60UHFM reduce the rate of single/double-strand DNA breaks and amount of chromosomal breaks. The radioprotective activity of C60UHFM was estimated by the survival rate of animals; the dose modification factor for animal survival was 1.3. Hematological tests showed that C60UHFM injection in mice prior to irradiation results in a decrement of irradiation-induced leucopenia and thrombocytopenia. Histological analysis testified that C60UHFM provide significant protection of small intestine tissues in mice against irradiation-induced damage. The obtained data assume that the radioprotective properties of C60UHFM are determined by their antioxidant, antiradical and DNA-protective qualities. Thus, it was demonstrated that C60UHFM are a novel antioxidant and radioprotective agent capable of substantial reduction of the harmful effects of ionizing radiation.

Citations

Jan 10, 2019·Antioxidants·Mars G SharapovSergey V Gudkov
May 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bee Ling Tan, Mohd Esa Norhaizan
Nov 1, 2020·International Journal of Molecular Sciences·Sergey V GudkovIvan A Scherbakov
Feb 2, 2021·Colloids and Surfaces. B, Biointerfaces·Jiangang XuXiaoyu Mu
Aug 11, 2021·The Journal of Physical Chemistry. B·Vladimir V SharoykoKonstantin N Semenov
Jan 31, 2019·The Journal of Physical Chemistry. B·Aleksander V SimakinSergey V Gudkov

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