Unnecessary surgery can be avoided by judicious use of PET/CT scanning in colorectal cancer patients.

Journal of Gastrointestinal Cancer
Aliasger AminJasim Amin

Abstract

This study aims to determine the role of positron emission tomography (PET)/computed tomography (CT) in changing the management plan in patients with metastatic or recurrent colorectal cancer (CRC) and to evaluate the role of PET/CT in patients with an unexplained rise in carcinoembryonic antigen (CEA). A total of 60 consecutive patients with CRC, who had PET/CT, were identified between 2008 and 2010. All patients had CT scans prior to the PET/CT. Data were collected from clinic letters, CT and PET CT reports and pathology results and cross-checked with the patient's notes. Patients were aged between 43 and 85 years [33 males, 27 females]. CEA was raised in 37 patients and normal in 23. Results of PET/CT were compared with that of CT scan and 33 out of the 60 patients (55%) had PET/CT results which were different to that of CT scan and 27 patients (45%) had similar PET/CT and CT results. PET scan appropriately altered the management in 23/60 patients (38%) and avoided unnecessary surgery in 14 patients. PET/CT had a sensitivity of 86% and specificity of 84%. In patients with an unexplained rise in CEA, PET/CT was positive in only one out of ten (10%) patients. PET/CT is valuable in deciding the management outcome in patients wi...Continue Reading

References

Aug 25, 1993·JAMA : the Journal of the American Medical Association·C G MoertelC Tangen
Jan 1, 1996·American Journal of Surgery·J V VitolaC W Pinson
Mar 10, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P FlamenL Mortelmans
Apr 5, 2000·AJR. American Journal of Roentgenology·K L BergerB A Siegel
Jan 11, 2001·Clinical Positron Imaging : Official Journal of the Institute for Clinical P.E.T·A MaldonadoM Zomeño
Apr 21, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P FlamenL Mortelmans
Jan 12, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T J M RuersW J G Oyen
Apr 30, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J Kievit
Nov 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel J SargentAimery De Gramont
Nov 23, 2006·Diseases of the Colon and Rectum·A J M WatsonF A Frizelle
Mar 26, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce E HillnerR Edward Coleman
Oct 11, 2008·International Journal of Cancer. Journal International Du Cancer·Chenpeng ZhangGang Huang
Jul 28, 2010·Abdominal Imaging·Yoshiko BambaShingo Kameoka
Jan 5, 2011·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·C JonesG Ellis

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Citations

Oct 24, 2014·AJR. American Journal of Roentgenology·Ankit AgarwalRathan M Subramaniam
Aug 13, 2015·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Michael GadeLars J Petersen
Dec 15, 2015·The Cochrane Database of Systematic Reviews·Brian D NicholsonDavid Mant
Mar 18, 2015·World Journal of Gastroenterology : WJG·Eun-Joo JungDae-Yong Hwang

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