Jan 1, 1989

Unoccupied prolactin binding components of the benign and malignant human prostate in a subclinical and clinical procedure

International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology
M TarleI Kokić

Abstract

Optimal conditions for the quantitation of free prolactin binding components of human prostatic tissue obtained by TURP were studied by applying gamma receptor assay. The radioligand used was 125I-prolactin. Significantly greater heat stability of the prostate membrane prolactin binding sites, when compared to that of androgen cytoplasmic receptors, was confirmed. The saturability and specificity of the prolactin binding components was demonstrated by the results of both Scatchard plot analysis and displacement studies. Free prolactin receptors were found in none of the poorly differentiated (G3) prostatic tumors examined, and only in 62.5% of medium differentiated (G2) prostatic malignancies. The majority of tissue specimens coming from patients with either BPH or well differentiated prostatic tumor (G1) contain measureable amounts of free prolactin membrane binding components. In the present study we report also the case in which the change in tumor differentiation toward a higher grade (G2 to G1, provoked by the successful chemohormonal treatment) is accompanied with the appearance of previously absent free prolactin binding components. In histologically proven BPH tissue specimens free prolactin receptor negative status has...Continue Reading

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Citations

Mentioned in this Paper

PRL
Prostatic Neoplasms
Receptors, Cytoplasmic
Prostatic Tissue
Neoplasms
Prostatic tissue preparation
PRLR gene
Androgens
Prostate Carcinoma
Adenoma

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