Unpacking Genetic Risk Pathways for College Student Alcohol Consumption: The Mediating Role of Impulsivity

Alcoholism, Clinical and Experimental Research
Albert J KsinanDanielle M Dick

Abstract

The period of college represents a particularly risky developmental stage with regard to alcohol use, as college students engage in more risky drinking behaviors than their noncollege peers, and such problematic alcohol use is associated with far-reaching negative consequences. Existing findings from genome-wide association studies (GWAS) indicate that alcohol consumption has a complex polygenic etiology. Currently, there is a lack of studies examining genetic risk for alcohol consumption using polygenic risk scores (PRS) in college samples. In this study, we examined whether alcohol-specific and risky behavior-related PRS were longitudinally associated with alcohol consumption among college students and whether this effect might be partially mediated by impulsivity domains. The sample included n = 2,385 European ancestry (EA) and n = 1,153 African ancestry (AA) college students assessed over the course of 4 years. To indicate genetic risk, 2 PRS were created based on recent large-scale GWAS: alcohol consumption (Liu et al., 2019) -drinks per week (DPW)-PRS and risky behaviors (Linnér et al., 2019) -RISK-PRS. The main outcome was alcohol consumption, measured across 4 waves of follow-up data. The UPPS-P impulsivity subscales we...Continue Reading

References

May 1, 1996·Journal of Studies on Alcohol·S A BrownM A Mott
May 23, 2002·Journal of Studies on Alcohol. Supplement·H Wesley Perkins
Aug 28, 2003·Experimental and Clinical Psychopharmacology·Stephen P Whiteside, Donald R Lynam
Sep 8, 2004·Archives of General Psychiatry·Brian M HicksChristopher J Patrick
Dec 14, 2005·Addictive Behaviors·James B Hittner, Rhonda Swickert
Mar 17, 2006·Current Psychiatry Reports·Danielle M Dick, Laura J Bierut
Jun 30, 2009·Journal of Studies on Alcohol and Drugs. Supplement·Ralph W HingsonElissa R Weitzman
Feb 13, 2010·Addiction Biology·Danielle M DickKenneth Sher
Mar 23, 2010·Journal of American College Health : J of ACH·Grace M BarnesMarie-Cecile O Tidwell
Apr 21, 2010·Addiction·James D SargentReiner Hanewinkel
May 25, 2010·Alcoholism, Clinical and Experimental Research·C W LejuezHarriet de Wit
May 25, 2010·Alcoholism, Clinical and Experimental Research·Laura MacPhersonC W Lejuez
Jan 12, 2011·Annual Review of Clinical Psychology·Danielle M Dick
Apr 20, 2011·Journal of Consulting and Clinical Psychology·Patricia J ConrodClare Mackie
Jun 22, 2011·Alcoholism, Clinical and Experimental Research·Danielle M DickKenneth S Kendler
Apr 9, 2013·Clinical Psychology Review·Kaidy Stautz, Andrew Cooper
Apr 13, 2013·Alcoholism, Clinical and Experimental Research·Ayca CoskunpinarMelissa A Cyders
Aug 30, 2014·Psychological Medicine·B VerhulstK S Kendler
Feb 28, 2015·GigaScience·Christopher C ChangJames J Lee
Jun 26, 2015·Alcoholism, Clinical and Experimental Research·Amy B Hart, Henry R Kranzler
Dec 17, 2015·Psychological Medicine·L KhemiriN Jayaram-Lindström
Apr 12, 2016·Genetic Epidemiology·Frank Dudbridge
Apr 20, 2016·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Nicola C NewtonMaree Teesson
May 24, 2016·Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors·Jessica E SalvatoreDanielle M Dick
Oct 14, 2016·Nature·Alice B Popejoy, Stephanie M Fullerton
Apr 4, 2017·American Journal of Human Genetics·Alicia R MartinEimear E Kenny
May 13, 2017·Journal of Studies on Alcohol and Drugs·James J LiDanielle M Dick

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Citations

Nov 7, 2019·Alcoholism, Clinical and Experimental Research·Angela M HaenyStephanie S O'Malley
Aug 12, 2020·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·John KramerLaura Acion

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