Unpacking the Pathogen Box-An Open Source Tool for Fighting Neglected Tropical Disease

Clinton G L Veale


The Pathogen Box is a 400-strong collection of drug-like compounds, selected for their potential against several of the world's most important neglected tropical diseases, including trypanosomiasis, leishmaniasis, cryptosporidiosis, toxoplasmosis, filariasis, schistosomiasis, dengue virus and trichuriasis, in addition to malaria and tuberculosis. This library represents an ensemble of numerous successful drug discovery programmes from around the globe, aimed at providing a powerful resource to stimulate open source drug discovery for diseases threatening the most vulnerable communities in the world. This review seeks to provide an in-depth analysis of the literature pertaining to the compounds in the Pathogen Box, including structure-activity relationship highlights, mechanisms of action, related compounds with reported activity against different diseases, and, where appropriate, discussion on the known and putative targets of compounds, thereby providing context and increasing the accessibility of the Pathogen Box to the drug discovery community.


Apr 1, 1977·Journal of Medicinal Chemistry·B P Das, David W Boykin
Dec 1, 1991·The Journal of Clinical Investigation·P A BermanJ A Freese
Jul 1, 1980·Journal of Medicinal Chemistry·E D Clercq, O Dann
Aug 1, 1980·Antimicrobial Agents and Chemotherapy·J AnnéO Dann
Mar 17, 1995·Journal of Medicinal Chemistry·David W BoykinRichard R Tidwell
Feb 10, 1995·Cell·H P Erickson
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·Alan F CowmanJ K Thompson
Feb 1, 1993·Antimicrobial Agents and Chemotherapy·D R AshtekarW Rittel
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M M ChanD Fong
Jul 19, 1996·Journal of Medicinal Chemistry·G R BrownM J Taylor
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·N SinC M Crews
Apr 16, 1998·Current Biology : CB·A C BishopKevan M Shokat
Apr 18, 1998·The Journal of Biological Chemistry·D K Giang, B F Cravatt
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·W Todd LowtherBrian W Matthews
Oct 22, 1998·Molecular Microbiology·Valerie Mizrahi, S J Andersen
Dec 8, 1998·The Journal of Infectious Diseases·L A SanniN H Hunt
Dec 29, 1998·Journal of Bacteriology·Cynthia A Hale, Piet A J de Boer
May 1, 1999·Antimicrobial Agents and Chemotherapy·Tina Skinner-Adams, T M Davis
Jun 9, 1999·Bioorganic & Medicinal Chemistry Letters·Fabio ZuccottoIan H Gilbert
Aug 26, 1999·Nature Neuroscience·J E Richmond, E M Jorgensen
Feb 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·J J De VossClifton E Barry
Feb 9, 2000·The Journal of Clinical Psychiatry·J P Feighner, K Overø
Mar 14, 2000·Natural Product Reports·A F VergneM J Miller
May 3, 2000·Seminars in Hematology·A O Pogo, A Chaudhuri
Jun 24, 2000·Bioorganic & Medicinal Chemistry Letters·Anne Kristin BakkestuenJ M Nolsøe
Jun 27, 2000·Journal of Bacteriology·E L WhiteD W Borhani
Sep 9, 2000·FEMS Microbiology Reviews·M BraibantJ Content
Dec 20, 2000·Antimicrobial Agents and Chemotherapy·H LauC H Sibley
Jan 23, 2001·The Journal of Biological Chemistry·H KieschnickC Beckers
Mar 10, 2001·International Journal for Parasitology·Rima McLeodDavid W Rice
May 18, 2001·Journal of Medicinal Chemistry·C E StephensDavid W Boykin
Jun 27, 2001·The American Journal of Tropical Medicine and Hygiene·J F Trape
Jul 14, 2001·European Journal of Medicinal Chemistry·Fabio ZuccottoIan H Gilbert
Nov 15, 2001·The Journal of Biological Chemistry·Nguyen Tien HuySaburo Hara
Jan 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ritu BanerjeeDaniel E Goldberg
Jan 26, 2002·Journal of Biomedical Science·Pent ZhangPeter K Chiang
Mar 9, 2002·Science·Amélie v Saint AndréEric Pearlman
Apr 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·Roya Zoraghi, Thomas Seebeck
Apr 12, 2002·Journal of Bacteriology·Cynthia A Hale, Piet A J de Boer
Apr 17, 2002·Journal of Molecular Biology·Sebastian Maurer-StrohFrank Eisenhaber
May 23, 2002·Antimicrobial Agents and Chemotherapy·Antonio Javier Martín-GalianoAdela G de la Campa
May 30, 2002·The Biochemical Journal·Timothy J EganJason C Walden
May 30, 2002·The Journal of Biological Chemistry·Colleen M NiswenderG Stanley McKnight
Jun 27, 2002·Biochimica Et Biophysica Acta·Ian H Gilbert
Jul 4, 2002·The Journal of Antimicrobial Chemotherapy·E Lucile WhiteRobert C Reynolds
Jul 18, 2002·Nature Reviews. Drug Discovery·Margaret A Somerville
Jul 18, 2002·Antimicrobial Agents and Chemotherapy·Michael A RielWilbur K Milhous
Jul 23, 2002·Current Pharmaceutical Design·Philip J RosenthalBhaskar R Shenai
Aug 2, 2002·Expert Opinion on Investigational Drugs·Nafsika H Georgopapadakou
Aug 6, 2002·Bioorganic & Medicinal Chemistry Letters·Gautam BhattacharyaKarl A Werbovetz
Sep 5, 2002·Medicinal Research Reviews·Lyann M B Ursos, Paul D Roepe
Dec 7, 2002·Bioorganic & Medicinal Chemistry·Thomas R WebbKenneth A Jacobson
Dec 7, 2002·Molecular and Biochemical Parasitology·Julio A UrbinaRenee Lira
Dec 12, 2002·Chemical Reviews·W Todd Lowther, Brian W Matthews
Mar 11, 2003·Microbiology and Molecular Biology Reviews : MMBR·Jeffery ErringtonDirk-Jan Scheffers
Jun 5, 2003·Bioorganic & Medicinal Chemistry Letters·Chad E StephensDavid W Boykin
Jun 5, 2003·Journal of Cell Science·Jennie L Lovett, L David Sibley
Sep 23, 2003·Science·Travis HarrisonKasturi Haldar
Oct 18, 2003·Science·Feroz R PapaPeter Walter
Nov 1, 2003·Pharmacotherapy·Lynda S Welage
Nov 12, 2003·Biochemical Pharmacology·Curtis R Chong, David J Sullivan
Nov 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Richa RawatPeter J Tonge
Dec 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Damien PortevinChristophe Guilhot
Feb 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Boris StriepenJessica C Kissinger
Mar 24, 2004·Nature Reviews. Microbiology·L ChitsuloD Engels
Mar 27, 2004·Science·Mitchell S AbrahamsenVivek Kapur
Apr 28, 2004·Bioorganic & Medicinal Chemistry·Christopher J AquinoMilana Dezube
May 25, 2004·Antimicrobial Agents and Chemotherapy·Michelle L GattonQin Cheng
Jun 25, 2004·Journal of Medicinal Chemistry·Akihiko TanitameJun-ichi Yamagishi
Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sylvie G BernierGerhard Hannig
Aug 26, 2004·Antimicrobial Agents and Chemotherapy·Andrea L CrowellW Evan Secor
Sep 11, 2004·Biochemical and Biophysical Research Communications·Nirianne Marie Q PalacpacToshihide Mitamura
Oct 20, 2004·The Journal of Biological Chemistry·A Levi Omara-OpyeneJohn B Dame
Nov 17, 2004·Insect Biochemistry and Molecular Biology·Li-Chun InfangerBruce M Christensen
Apr 2, 2005·Journal of Medicinal Chemistry·Anne Kristin BakkestuenBibigul T Utenova
Apr 6, 2005·Bioorganic & Medicinal Chemistry Letters·Eugenia KiselgofAhmad Fawzi
Apr 23, 2005·Acta Tropica·John E Hyde
May 10, 2005·Bioorganic & Medicinal Chemistry Letters·Anu AgarwalPrem M S Chauhan
Jun 1, 2005·Bioorganic & Medicinal Chemistry Letters·Tesfaye BiftuMatthew Wyvratt
Jul 16, 2005·Analytical and Bioanalytical Chemistry·Kaushik BanerjeeMichael Spiteller
Jul 27, 2005·Biochemical Society Transactions·Helen P PriceDeborah F Smith
Jul 29, 2005·Antimicrobial Agents and Chemotherapy·Olga SenkovichDebasish Chattopadhyay
Aug 6, 2005·Bioorganic & Medicinal Chemistry·Morten Braendvang, Lise-Lotte Gundersen
Sep 21, 2005·The Journal of Antimicrobial Chemotherapy·Marina ProtopopovaCarol A Nacy
Nov 2, 2005·Bioorganic & Medicinal Chemistry Letters·Andrew K TakleDavid M Wilson
Nov 11, 2005·Molecular and Biochemical Parasitology·Stefan KunzThomas Seebeck
Jan 6, 2006·Journal of Medicinal Chemistry·Ravindranadh V SomuCourtney C Aldrich
Jan 13, 2006·The FEBS Journal·Marcus MiethkeMohamed A Marahiel
Jan 13, 2006·Nature Chemical Biology·Julian A FerrerasLuis E N Quadri
Jan 27, 2006·The Journal of Biological Chemistry·Xiaoming TuChing C Wang
Jan 31, 2006·Bioorganic & Medicinal Chemistry·Prashanth AthriW David Wilson
Mar 7, 2006·Bioorganic & Medicinal Chemistry Letters·Xiaoxia QianTesfaye Biftu
Mar 9, 2006·BMC Microbiology·Andrea JohnerThomas Seebeck
Apr 6, 2006·The Journal of Antimicrobial Chemotherapy·Vadim MakarovUte Möllmann
Jul 19, 2006·Progress in Lipid Research·Ponniah SelvakumarRajendra K Sharma
Aug 8, 2006·International Journal for Parasitology·John J AlloccoBakela Nare
Aug 18, 2006·Journal of Medicinal Chemistry·Arpita Mitra, David Sept
Sep 20, 2006·Proceedings of the National Academy of Sciences of the United States of America·Xiaochun ChenJun O Liu
Oct 7, 2006·Applied Microbiology and Biotechnology·Waldemar Vollmer
Nov 25, 2006·Molecular and Biochemical Parasitology·Dominik KugelstadtBarbara Kappes
Dec 15, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michael OberholzerThomas Seebeck
Dec 22, 2006·Journal of Medicinal Chemistry·Ravindranadh V SomuCourtney C Aldrich
Dec 22, 2006·Journal of Medicinal Chemistry·Hirofumi SasakiHidetsugu Tsubouchi
Dec 22, 2006·Molecular Biology of the Cell·Helen P PriceDeborah F Smith
Feb 15, 2007·Expert Opinion on Therapeutic Targets·Christian Doerig, Laurent Meijer
Apr 19, 2007·Journal of Medicinal Chemistry·Donald A PatrickRichard R Tidwell
May 8, 2007·Medicinal Research Reviews·Qingning Shu, Vasu Nair
Jun 15, 2007·FEMS Microbiology Letters·Vlasta CtrnáctáIvan Hrdý
Jun 15, 2007·Bioorganic & Medicinal Chemistry Letters·Jason M CoxScott D Edmondson
Jun 21, 2007·Analytical and Bioanalytical Chemistry·Kaushik BanerjeeMichael Spiteller
Sep 1, 2007·The Journal of Antimicrobial Chemotherapy·Oluwabunmi Y SaliuRobert S Wallis
Sep 7, 2007·Bioorganic & Medicinal Chemistry·Morten Braendvang, Lise-Lotte Gundersen
Sep 7, 2007·Microbiology and Molecular Biology Reviews : MMBR·Marcus Miethke, Mohamed A Marahiel
Sep 26, 2007·Expert Review of Anticancer Therapy·Gerald M Higa, Jame Abraham
Nov 1, 2007·Infectious Disorders Drug Targets·K Mdluli, Z Ma
Dec 18, 2007·Experimental Parasitology·Rolf W WinterMichael K Riscoe
Jan 24, 2008·Antimicrobial Agents and Chemotherapy·Katherine T AndrewsDavid P Fairlie
Jan 30, 2008·The Journal of Experimental Medicine·Walid BeghdadiSalaheddine Mécheri
Mar 8, 2008·ChemMedChem·Paul W BowyerKatherine A Brown
Apr 1, 2008·The Journal of Parasitology·Einat ZeimanJacob Golenser
Apr 3, 2008·The Journal of Clinical Investigation·Ken StuartRick Tarleton
Apr 10, 2008·Journal of Medicinal Chemistry·Clive L YeatesMaría Luisa León
May 16, 2008·Tuberculosis·Laurel RespicioRichard A Slayden
Jun 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·David PlouffeElizabeth A Winzeler
Jul 12, 2008·Bioorganic & Medicinal Chemistry Letters·M Raymond V FinlayHazel M Weir
Jul 16, 2008·The Journal of Biological Chemistry·Anil KoulKoen Andries
Jul 30, 2008·Antimicrobial Agents and Chemotherapy·Eugene SkripkinFrançois Franceschi
Aug 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Srinivasa P S RaoKevin Pethe
Sep 26, 2008·Bioorganic & Medicinal Chemistry Letters·Malcolm AndersonHazel M Weir
Oct 10, 2008·Journal of Medicinal Chemistry·Stanislav A BakunovRichard R Tidwell
Oct 25, 2008·Bioorganic & Medicinal Chemistry Letters·Jiacheng ZhouGraham Johnson
Nov 4, 2008·Current Opinion in Infectious Diseases·Michael J DoenhoffJürg Utzinger
Nov 7, 2008·Bioorganic & Medicinal Chemistry Letters·Clifford D JonesHazel M Weir
Nov 11, 2008·Bioorganic & Medicinal Chemistry Letters·Clifford D JonesMike Walker
Dec 19, 2008·Bioorganic & Medicinal Chemistry Letters·Chitalu C MusondaMarcel Kaiser
Dec 19, 2008·Bioorganic & Medicinal Chemistry Letters·Nagarapu SrinivasKalpana Bhandari
Dec 31, 2008·Journal of Medicinal Chemistry·Sandra GemmaCaterina Fattorusso
Jan 21, 2009·The Journal of Biological Chemistry·Maxim PimkinGeorge D Markham
Feb 19, 2009·Antimicrobial Agents and Chemotherapy·Jinhong ChangTimothy M Block
Mar 17, 2009·Bioorganic & Medicinal Chemistry Letters·F GellibertN Dodic
Apr 15, 2009·Antimicrobial Agents and Chemotherapy·Georgina A HollowayJonathan B Baell
May 12, 2009·Bioorganic & Medicinal Chemistry Letters·Morten BraendvangLise-Lotte Gundersen
May 14, 2009·The Journal of Biological Chemistry·Sabine GavaldaAnnaïk Quémard
May 15, 2009·BMJ : British Medical Journal·Moses Bockarie, David H Molyneux
May 19, 2009·Bioorganic & Medicinal Chemistry Letters·Jeremy P MallariR Kiplin Guy
Jun 17, 2009·Cell Host & Microbe·Oliver BillkerL David Sibley
Jun 24, 2009·PloS One·Walid BeghdadiSalaheddine Mécheri
Jul 25, 2009·Journal of Medicinal Chemistry·Sushil K MauryaGregory D Cuny
Jul 31, 2009·Communicative & Integrative Biology·Ujjini ManjunathaClifton E Barry
Aug 28, 2009·Bioorganic & Medicinal Chemistry·Morten BraendvangLise-Lotte Gundersen
Sep 18, 2009·Tuberculosis·Subramaniam AnanthanE Lucile White
Sep 29, 2009·Molecular and Biochemical Parasitology·Helen P PriceDeborah F Smith
Sep 30, 2009·Antimicrobial Agents and Chemotherapy·Kirsten GillingwaterReto Brun
Oct 7, 2009·Current Opinion in Chemical Biology·Pui-Hang Tam, Todd L Lowary
Oct 31, 2009·The Journal of Biological Chemistry·Nathan A LackLindsay D Eltis
Nov 10, 2009·Journal of Chemical Biology·Megan H WrightEdward W Tate
Nov 17, 2009·Bioorganic & Medicinal Chemistry Letters·Kalpana BhandariSuman Gupta
Nov 17, 2009·Bioorganic & Medicinal Chemistry Letters·Derek C MartynJon Clardy
Nov 26, 2009·Journal of Medicinal Chemistry·Stanislav A BakunovRichard R Tidwell
Nov 26, 2009·Journal of Medicinal Chemistry·Petr NausMichal Hocek
Nov 26, 2009·Molecules and Cells·Sebastian Greiss, Anton Gartner
Dec 9, 2009·Journal of Medicinal Chemistry·Hamish S SutherlandAndrew M Thompson
Dec 25, 2009·Journal of Virology·Sina GhaemmaghamiStanley B Prusiner
Jan 8, 2010·Bioorganic & Medicinal Chemistry Letters·Neil GartonPaula Pickering
Feb 5, 2010·Nature·Justin A BoddeyAlan F Cowman
Feb 20, 2010·Bioorganic & Medicinal Chemistry Letters·Maya BergKoen Augustyns
Mar 20, 2010·Journal of Virology·Pornwaratt NiyomrattanakitPei-Yong Shi
Mar 26, 2010·Infectious Disorders Drug Targets·Margaret A Phillips, Pradipsinh K Rathod
Apr 3, 2010·Nature·Julie A FrearsonPaul G Wyatt
Apr 7, 2010·Antimicrobial Agents and Chemotherapy·Michael Zhuo WangKarl A Werbovetz
Apr 8, 2010·Cellular and Molecular Life Sciences : CMLS·Izabela A Rodenhuis-ZybertJolanda M Smit
May 4, 2010·Nature Structural & Molecular Biology·Kayode K OjoWesley C Van Voorhis
May 5, 2010·Nature Reviews. Microbiology·Michael A KohanskiJames J Collins
May 11, 2010·Bioorganic & Medicinal Chemistry·Norbert SchormannDebasish Chattopadhyay
May 12, 2010·Antimicrobial Agents and Chemotherapy·Denise da Gama Jaén BatistaMaria de Nazaré Correia Soeiro
May 21, 2010·Nature·Francisco-Javier GamoJosé Francisco García-Bustos
May 21, 2010·Journal of Clinical Laboratory Analysis·Rachel Beaulieu GoldsmithHoward M Reisner
May 22, 2010·Bioorganic & Medicinal Chemistry·Matthew L ReadLise-Lotte Gundersen
Jun 1, 2010·ChemMedChem·Alexandra Manos-TurveyRichard J Payne
Jun 25, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H OgawaS Sone
Jun 30, 2010·Current Drug Targets·José L MaurizJavier González-Gallego
Jul 21, 2010·Antimicrobial Agents and Chemotherapy·Dhruv Panchal, Purnima Bhanot
Aug 12, 2010·Journal of Medicinal Chemistry·Suresh K TipparajuRima L McLeod
Aug 13, 2010·The Journal of Biological Chemistry·Michael L BookerEdmund Sybertz
Aug 14, 2010·PLoS Neglected Tropical Diseases·Lisa SharlingBoris Striepen
Aug 25, 2010·Journal of Medicinal Chemistry·Gábor BorbélyGyörgy Kéri
Aug 27, 2010·Lancet·Mark J TaylorMoses Bockarie
Sep 4, 2010·Science·Matthias RottmannThierry T Diagana
Nov 3, 2010·Chemistry & Biology·Deviprasad R GollapalliLizbeth Hedstrom
Nov 3, 2010·Experimental Parasitology·Rolf W WinterMichael K Riscoe
Nov 5, 2010·Journal of Medicinal Chemistry·Werner J GeldenhuysMark A Simmons
Nov 16, 2010·Molecular and Biochemical Parasitology·Zdeněk VernerJulius Lukes
Dec 4, 2010·Journal of Medicinal Chemistry·Kunal KumarIwao Ojima
Dec 25, 2010·Journal of Chemical Information and Modeling·Kuei-Chung ShihChuan-Yi Tang
Jan 13, 2011·FEMS Microbiology Reviews·Matthew K Gould, Harry P de Koning
Jan 19, 2011·ACS Medicinal Chemistry Letters·Yiqun ZhangR Kiplin Guy
Feb 8, 2011·Bioorganic & Medicinal Chemistry Letters·Vijay K MarrapuKalpana Bhandari
Mar 2, 2011·Parasites & Vectors·Benoît MeslinAnne-Lise Bienvenu
Mar 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jun-Rong WeiEric J Rubin
Apr 5, 2011·The International Journal of Biochemistry & Cell Biology·Leann TilleyKiaran Kirk
Apr 28, 2011·Combinatorial Chemistry & High Throughput Screening·C John HarrisPieter F W Stouten
Jun 3, 2011·Bioorganic & Medicinal Chemistry Letters·Ruslana BrykJohn H Griffin
Jun 8, 2011·Journal of Medicinal Chemistry·Tao WuArnab K Chatterjee
Jun 11, 2011·Advances in Experimental Medicine and Biology·Philip J Rosenthal
Jun 15, 2011·Chemical Biology & Drug Design·Zachary B MackeyJames H McKerrow
Jul 9, 2011·PLoS Neglected Tropical Diseases·Robert JacobsRobert Don
Jul 12, 2011·Trends in Parasitology·Katherine E JacksonStuart A Ralph
Jul 26, 2011·Bioorganic & Medicinal Chemistry Letters·Robert H BradburyAndrew A Mortlock
Aug 24, 2011·Future Medicinal Chemistry·Robert JacobsRobert Don
Sep 3, 2011·PLoS Neglected Tropical Diseases·Rosario Diaz-GonzalezMichael P Pollastri
Oct 5, 2011·Journal of Medicinal Chemistry·Diego Gonzàlez CabreraKelly Chibale
Nov 5, 2011·The Journal of Antimicrobial Chemotherapy·Sidharth ChopraPeter B Madrid
Nov 19, 2011·Science·Stephan MeisterElizabeth A Winzeler
Dec 6, 2011·Journal of Enzyme Inhibition and Medicinal Chemistry·Gregory J GattoDouglas G Johns
Dec 14, 2011·Journal of Medicinal Chemistry·Stephen BrandIan H Gilbert
Dec 14, 2011·Antimicrobial Agents and Chemotherapy·Ana C PenaAna Pamplona
Dec 23, 2011·Journal of the American Chemical Society·Claudia TrefzerKai Johnsson
Jan 3, 2012·European Journal of Pharmacology·Kuncha MadhusudanaPrakash V Diwan
Feb 1, 2012·The Journal of Infectious Diseases·Harry P de KoningThomas Seebeck
Feb 14, 2012·Bioorganic & Medicinal Chemistry Letters·Britt-Marie SwahnStefan Berg
Mar 1, 2012·PloS One·David L Prole, Neil V Marrion
Mar 1, 2012·Journal of Medicinal Chemistry·Eric T LarsonEthan A Merritt
Apr 6, 2012·PloS One·Veeraraghavan UshaGurdyal S Besra
Apr 6, 2012·PloS One·Mingli LiuJonathan K Stiles
Apr 11, 2012·Journal of Medicinal Chemistry·Fu-Yang LinEric Oldfield
Apr 18, 2012·Antimicrobial Agents and Chemotherapy·Subathdrage D M SumanadasaKatherine T Andrews
Apr 24, 2012·Journal of Medicinal Chemistry·Matthias D'hoogheNorbert De Kimpe
Apr 25, 2012·Journal of Medicinal Chemistry·Advait NagleArnab K Chatterjee
Apr 25, 2012·Proceedings of the National Academy of Sciences of the United States of America·Karen McLuskeyJeremy C Mottram
Jun 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Sarah M BattGurdyal S Besra
Jul 26, 2012·Future Microbiology·Katherine A SackstederCarol A Nacy
Aug 15, 2012·European Journal of Medicinal Chemistry·Stefan O OchianaMichael P Pollastri
Aug 22, 2012·Molecular and Biochemical Parasitology·Agnieszka A Religa, Andrew P Waters
Aug 25, 2012·Journal of Medicinal Chemistry·Tomislav KaroliMatthew A Cooper
Sep 8, 2012·Science Translational Medicine·João NeresClaudia Binda
Sep 19, 2012·Bioorganic & Medicinal Chemistry·Michal TichýMichal Hocek
Sep 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Nicholas A MalmquistMatthew J Fuchter
Oct 10, 2012·ACS Chemical Biology·Jill M CombrinckTimothy J Egan
Oct 30, 2012·Chemistry & Biology·D Grahame HardieSimon A Hawley
Nov 13, 2012·PLoS Neglected Tropical Diseases·Matthias WitschelReto Brun
Nov 30, 2012·Journal of Medicinal Chemistry·Diego Gonzàlez CabreraKelly Chibale
Jan 1, 2013·Bioorganic & Medicinal Chemistry·Katarzyna MichalskaStefan Tyski
Jan 1, 2013·Experimental Parasitology·Audrey O T LauPurnima Bhanot
Jan 10, 2013·PloS One·Katherine A AbrahamsGurdyal S Besra
Jan 12, 2013·ChemMedChem·Lluis BallellNicholas Cammack
Jan 18, 2013·Bioorganic & Medicinal Chemistry Letters·Corey R JohnsonLizbeth Hedstrom
Feb 12, 2013·Bioorganic & Medicinal Chemistry Letters·Tyrell TowlePurnima Bhanot
Feb 14, 2013·Journal of the American Chemical Society·Rohit TiwariMarvin J Miller
Feb 19, 2013·Bioorganic & Medicinal Chemistry Letters·Sunghyun KangSemi Kim
Mar 5, 2013·Bioorganic & Medicinal Chemistry Letters·Gang ChengRima McLeod
Mar 8, 2013·Bioorganic & Medicinal Chemistry Letters·Robert H BradburyJ Matthew Wood
Mar 20, 2013·Bioorganic & Medicinal Chemistry·Pengtao ZhangDawei Ma
Mar 26, 2013·Nature Chemical Biology·Mercedes LoberaMichael A Nolan
Mar 29, 2013·Journal of Biomolecular Screening·William R ShadrickDavid N Frick
May 3, 2013·Journal of Medicinal Chemistry·Feiran ZhangJun O Liu
Jun 19, 2013·Nature Chemical Biology·Regina WilsonDavid Alland
Jun 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Feng WangPeter G Schultz
Jun 22, 2013·The Journal of Infectious Diseases·P Vineel ReddyAnil K Tyagi
Jun 26, 2013·Journal of Medicinal Chemistry·Donald A PatrickRichard R Tidwell
Aug 7, 2013·Bioorganic & Medicinal Chemistry Letters·Susan J Ramos-HunterGary A Sulikowski
Aug 8, 2013·Future Medicinal Chemistry·Kim Y Fong, David W Wright
Aug 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Quin H ChristensenE Peter Greenberg
Aug 13, 2013·The Journal of Biological Chemistry·Olivia VergnolleJohn S Blanchard
Aug 21, 2013·Current Pharmaceutical Design·David SheppardPieter F W Stouten
Sep 17, 2013·Applied Microbiology and Biotechnology·Giovanna RiccardiClaudia Binda
Nov 6, 2013·Journal of Medicinal Chemistry·Stéphanie GourdainRobert H Dodd
Nov 16, 2013·Nature·Boris Striepen
Nov 26, 2013·Bioorganic & Medicinal Chemistry·Donald A PatrickRichard R Tidwell
Nov 29, 2013·Nature·Case W McNamaraElizabeth A Winzeler
Dec 7, 2013·Journal of Medicinal Chemistry·Martine KeenanSusan A Charman
Aug 1, 1986·Journal of Chemical Ecology·I Popiel
Dec 7, 2013·Science Translational Medicine·Srinivasa P S RaoUjjini Manjunatha
Dec 20, 2013·Nature·Frédéric ArieyDidier Menard
Dec 20, 2013·Nature Communications·Shichun LunWilliam Bishai
Dec 21, 2013·Journal of Medicinal Chemistry·Hari Babu TatipakaMichael H Gelb
Dec 25, 2013·Antimicrobial Agents and Chemotherapy·Suresh Kumar GorlaLizbeth Hedstrom
Jan 2, 2014·Proceedings of the National Academy of Sciences of the United States of America·Amanda K LukensDyann F Wirth
Jan 16, 2014·Journal of Infection in Developing Countries·Suvash Chandra OjhaPankaj Baral
Jan 22, 2014·The Biochemical Journal·Adam J RobertsAlan H Fairlamb
Jan 23, 2014·Journal of Medicinal Chemistry·Diego Gonzàlez CabreraKelly Chibale
Jan 31, 2014·Parasitology·Lisa J IoannidisDiana S Hansen
Feb 7, 2014·EMBO Molecular Medicine·Vadim MakarovStewart T Cole
Dec 1, 2011·International Journal for Parasitology. Drugs and Drug Resistance·Adrian J Wolstenholme
Feb 27, 2014·Journal of Medicinal Chemistry·Kai LiEric Oldfield
Mar 8, 2014·European Journal of Medicinal Chemistry·Mohammad A KhanfarRichard B Silverman
Mar 8, 2014·The Journal of Infectious Diseases·Nicolas Dubois-ColasLudovic Tailleux
Mar 14, 2014·Journal of Agricultural and Food Chemistry·Johan P van den HeeverStephen F Pernal
Mar 26, 2014·Antimicrobial Agents and Chemotherapy·Ming ZhangStewart T Cole
Mar 29, 2014·Bioorganic & Medicinal Chemistry Letters·Pradip JadavPraveen Kumar Singh
Mar 29, 2014·European Journal of Drug Metabolism and Pharmacokinetics·Agnieszka KarbownikEdmund Grześkowiak
Apr 2, 2014·Antimicrobial Agents and Chemotherapy·J Stone DoggettWesley C Van Voorhis
Apr 12, 2014·Journal of Medicinal Chemistry·Aaron NilsenMichael K Riscoe
Apr 16, 2014·Malaria Journal·Julie LothariusTimothy N C Wells
May 3, 2014·PLoS Pathogens·Na ShangRey-Ting Guo
May 14, 2014·Journal of Medicinal Chemistry·Manoranjan PandaAnandkumar Raichurkar
May 31, 2014·Journal of Medicinal Chemistry·Pravin S ShirudeMonalisa Chatterji
Jul 8, 2010·ACS Medicinal Chemistry Letters·Dazhong DingJacob J Plattner
Oct 13, 2011·ACS Medicinal Chemistry Letters·Félix CalderónJulia Castro
Nov 10, 2011·ACS Medicinal Chemistry Letters·Lourdes RuedaEsther Fernandez
Dec 13, 2012·ACS Medicinal Chemistry Letters·Sharad K VermaWilliam H Miller
Jun 6, 2014·ACS Medicinal Chemistry Letters·Hideyuki SuzukiTsutomu Iwaki
Jun 6, 2014·ACS Medicinal Chemistry Letters·Marvin J MeyersXiaoping Chen
Jun 10, 2014·MedChemComm·Gautam PatelMichael P Pollastri
Jun 14, 2014·Drugs·Nicola J Ryan, Jin Han Lo
Jul 1, 2014·Journal of Medicinal Chemistry·Lori FerrinsJonathan B Baell
Jul 18, 2014·PLoS Neglected Tropical Diseases·Joseph D PlanerFrederick S Buckner
Jul 23, 2014·Antimicrobial Agents and Chemotherapy·Daniela BegoloChristine Clayton
Jul 31, 2014·The New England Journal of Medicine·Elizabeth A AshleyTracking Resistance to Artemisinin Collaboration (TRAC)
Aug 1, 2014·European Journal of Medicinal Chemistry·Ratchanok PingaewVirapong Prachayasittikul
Aug 15, 2014·Cell Host & Microbe·Bradley I ColemanManoj T Duraisingh
Aug 26, 2014·Journal of Medicinal Chemistry·R Matthew CrossRoman Manetsch
Aug 27, 2014·Antimicrobial Agents and Chemotherapy·Kriti AroraHelena I Boshoff
Sep 13, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gaëlle Mariaule, Philippe Belmont
Sep 23, 2014·Journal of Medicinal Chemistry·Jennie A HuttonEdward W Tate
Oct 8, 2014·Bioorganic & Medicinal Chemistry Letters·Matthew G LaPorteDonna M Huryn
Oct 22, 2014·Antimicrobial Agents and Chemotherapy·A M UptonScott G Franzblau
Oct 29, 2014·Antimicrobial Agents and Chemotherapy·Anusha M Gopalakrishnan, Nirbhay Kumar
Dec 3, 2014·Bioorganic & Medicinal Chemistry Letters·Thomas JensenStephen P Watson
Dec 4, 2014·Bioorganic & Medicinal Chemistry·Ahmed KamalChandrakant Bagul
Dec 6, 2014·Advances in Microbial Physiology·Gregory M CookMichael Berney
Dec 10, 2014·Antimicrobial Agents and Chemotherapy·Suresh B LakshminarayanaFrancesca Blasco
Dec 18, 2014·International Journal for Parasitology. Drugs and Drug Resistance·Rebecca D SandlinDavid W Wright
Jan 13, 2015·The Journal of Biological Chemistry·Magdalena Makowska-GrzyskaAndrzej Joachimiak
Jan 15, 2015·Antimicrobial Agents and Chemotherapy·Phercyles Veiga-SantosEric Oldfield
Jan 16, 2015·ACS Medicinal Chemistry Letters·Jing DongAmedeo Caflisch
Feb 5, 2015·Molecular Therapy : the Journal of the American Society of Gene Therapy·Alyse N DouglassAlexis Kaushansky
Feb 24, 2015·ACS Chemical Biology·Wenxia FangDaan M F van Aalten
Feb 28, 2015·European Journal of Medicinal Chemistry·Ryan M YoungMichael T Davies-Coleman
Mar 21, 2015·The European Respiratory Journal·Knut LönnrothMario C Raviglione
Mar 31, 2015·Cold Spring Harbor Perspectives in Medicine·Luke J AlderwickHelen L Birch
Apr 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Katy N OlafsonPeter G Vekilov
Apr 17, 2015·Malaria Journal·WHO Malaria Policy Advisory Committee and Secretariat
Apr 24, 2015·ACS Chemical Biology·Miroslav BrecikKatarína Mikušová
Jun 4, 2015·Journal of Medicinal Chemistry·Jeremy GreenSteve Rodems
Jun 7, 2015·Biochemical Pharmacology·Nicolas MontalbettiMatthias A Hediger
Jun 10, 2015·The Journal of Biological Chemistry·Devaraja G MudeppaPradipsinh K Rathod
Jun 19, 2015·Nature·Beatriz BaragañaIan H Gilbert
Jun 19, 2015·Journal of Medicinal Chemistry·William DevineMichael P Pollastri
Jun 26, 2015·Journal of Medicinal Chemistry·Kathryn M NelsonCourtney C Aldrich
Jul 1, 2015·Antimicrobial Agents and Chemotherapy·Galen P MileyMichael K Riscoe
Jul 5, 2015·Blood Cells, Molecules & Diseases·Vrushali PathakKanjaksha Ghosh
Jul 11, 2015·Nature Communications·Jan RybnikerStewart T Cole
Aug 2, 2015·European Journal of Medicinal Chemistry·José Wanderlan Pontes EspíndolaAna Cristina Lima Leite
Aug 8, 2015·The Journal of Antimicrobial Chemotherapy·Susan E KnudsonRichard A Slayden
Aug 17, 2015·Drug and Alcohol Dependence·Saul ShiffmanStuart G Ferguson
Sep 1, 2015·Journal of Medicinal Chemistry·Diego Gonzàlez CabreraKelly Chibale
Sep 30, 2015·Journal of Medicinal Chemistry·Laura A T CleghornIan H Gilbert
Oct 6, 2015·Nature Reviews. Drug Discovery·Kei KatsunoB T Slingsby
Oct 13, 2015·Journal of Medicinal Chemistry·Oscar AubiJarl Underhaug
Oct 29, 2015·Bioorganic & Medicinal Chemistry Letters·Yong-Kang ZhangWuxin Zou
Nov 25, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Gregory G Simon
Dec 20, 2015·PLoS Neglected Tropical Diseases·Deuan C JonesAlan H Fairlamb
Jan 29, 2016·ACS Chemical Biology·Willie W HsuWenshe R Liu
Feb 11, 2016·International Journal for Parasitology. Drugs and Drug Resistance·Roman DeniskinMyles H Akabas
Feb 11, 2016·ACS Chemical Biology·Susan KlaegerBernhard Kuster
May 14, 2016·Nature Reviews. Microbiology·Ying Kai Chan, Michaela U Gack
May 24, 2016·European Journal of Medicinal Chemistry·Samaneh Ghanei-NasabAbbas Shafiee
May 31, 2016·European Journal of Medicinal Chemistry·Daniela De VitaMaurizio Botta