Unpacking the Pathogen Box-An Open Source Tool for Fighting Neglected Tropical Disease

ChemMedChem
Clinton G L Veale

Abstract

The Pathogen Box is a 400-strong collection of drug-like compounds, selected for their potential against several of the world's most important neglected tropical diseases, including trypanosomiasis, leishmaniasis, cryptosporidiosis, toxoplasmosis, filariasis, schistosomiasis, dengue virus and trichuriasis, in addition to malaria and tuberculosis. This library represents an ensemble of numerous successful drug discovery programmes from around the globe, aimed at providing a powerful resource to stimulate open source drug discovery for diseases threatening the most vulnerable communities in the world. This review seeks to provide an in-depth analysis of the literature pertaining to the compounds in the Pathogen Box, including structure-activity relationship highlights, mechanisms of action, related compounds with reported activity against different diseases, and, where appropriate, discussion on the known and putative targets of compounds, thereby providing context and increasing the accessibility of the Pathogen Box to the drug discovery community.

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Mar 21, 2015·The European Respiratory Journal·Knut LönnrothMario C Raviglione
Mar 31, 2015·Cold Spring Harbor Perspectives in Medicine·Luke J AlderwickHelen L Birch
Apr 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Katy N OlafsonPeter G Vekilov
Apr 17, 2015·Malaria Journal·WHO Malaria Policy Advisory Committee and Secretariat
Apr 24, 2015·ACS Chemical Biology·Miroslav BrecikKatarína Mikušová
Jun 4, 2015·Journal of Medicinal Chemistry·Jeremy GreenSteve Rodems
Jun 7, 2015·Biochemical Pharmacology·Nicolas MontalbettiMatthias A Hediger
Jun 10, 2015·The Journal of Biological Chemistry·Devaraja G MudeppaPradipsinh K Rathod
Jun 19, 2015·Nature·Beatriz BaragañaIan H Gilbert
Jun 19, 2015·Journal of Medicinal Chemistry·William DevineMichael P Pollastri
Jun 26, 2015·Journal of Medicinal Chemistry·Kathryn M NelsonCourtney C Aldrich
Jul 1, 2015·Antimicrobial Agents and Chemotherapy·Galen P MileyMichael K Riscoe
Jul 5, 2015·Blood Cells, Molecules & Diseases·Vrushali PathakKanjaksha Ghosh
Jul 11, 2015·Nature Communications·Jan RybnikerStewart T Cole
Aug 2, 2015·European Journal of Medicinal Chemistry·José Wanderlan Pontes EspíndolaAna Cristina Lima Leite
Aug 8, 2015·The Journal of Antimicrobial Chemotherapy·Susan E KnudsonRichard A Slayden
Aug 17, 2015·Drug and Alcohol Dependence·Saul ShiffmanStuart G Ferguson
Sep 1, 2015·Journal of Medicinal Chemistry·Diego Gonzàlez CabreraKelly Chibale
Sep 30, 2015·Journal of Medicinal Chemistry·Laura A T CleghornIan H Gilbert
Oct 6, 2015·Nature Reviews. Drug Discovery·Kei KatsunoB T Slingsby
Oct 13, 2015·Journal of Medicinal Chemistry·Oscar AubiJarl Underhaug
Oct 29, 2015·Bioorganic & Medicinal Chemistry Letters·Yong-Kang ZhangWuxin Zou
Nov 25, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Gregory G Simon
Dec 20, 2015·PLoS Neglected Tropical Diseases·Deuan C JonesAlan H Fairlamb
Jan 29, 2016·ACS Chemical Biology·Willie W HsuWenshe R Liu
Feb 11, 2016·International Journal for Parasitology. Drugs and Drug Resistance·Roman DeniskinMyles H Akabas
Feb 11, 2016·ACS Chemical Biology·Susan KlaegerBernhard Kuster
May 14, 2016·Nature Reviews. Microbiology·Ying Kai Chan, Michaela U Gack
May 24, 2016·European Journal of Medicinal Chemistry·Samaneh Ghanei-NasabAbbas Shafiee
May 31, 2016·European Journal of Medicinal Chemistry·Daniela De VitaMaurizio Botta