Unprecedented Potential for Neural Drug Discovery Based on Self-Organizing hiPSC Platforms

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Agustin Cota-CoronadoN Emmanuel Diaz-Martinez

Abstract

Human induced pluripotent stem cells (hiPSCs) have transformed conventional drug discovery pathways in recent years. In particular, recent advances in hiPSC biology, including organoid technologies, have highlighted a new potential for neural drug discovery with clear advantages over the use of primary tissues. This is important considering the financial and social burden of neurological health care worldwide, directly impacting the life expectancy of many populations. Patient-derived iPSCs-neurons are invaluable tools for novel drug-screening and precision medicine approaches directly aimed at reducing the burden imposed by the increasing prevalence of neurological disorders in an aging population. 3-Dimensional self-assembled or so-called 'organoid' hiPSCs cultures offer key advantages over traditional 2D ones and may well be gamechangers in the drug-discovery quest for neurological disorders in the coming years.

References

Nov 25, 2003·Nature Reviews. Genetics·David B GoldsteinSanjay M Sisodiya
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·William M Pardridge
Aug 30, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·William M Pardridge
Dec 24, 2013·The Journal of Biological Chemistry·Sandra J Engle, Fabien Vincent
Mar 14, 2014·Expert Opinion on Drug Discovery·Alessandro PoliniAli Khademhosseini
Feb 18, 2015·Accounts of Chemical Research·Jean-Louis Reymond
Feb 26, 2016·Nature Cell Biology·Aliya FatehullahNick Barker
Jul 13, 2016·Developmental Biology·Iva Kelava, Madeline A Lancaster
Oct 25, 2016·Neurochemistry International·Brigham J Hartley, Kristen J Brennand
Mar 16, 2017·Development·Meritxell HuchAlfonso Martinez-Arias
Apr 12, 2017·Stem Cells and Development·Karin LauschkeVanessa Jane Hall
Jun 1, 2017·Nature Biotechnology·Madeline A LancasterJuergen A Knoblich
Sep 8, 2017·Nature Reviews. Neuroscience·Elizabeth Di Lullo, Arnold R Kriegstein
Mar 23, 2018·Current Transplantation Reports·Elena GarretaJuan Carlos Izpisua Belmonte
Jun 6, 2018·Proceedings of the National Academy of Sciences of the United States of America·Koji TanabeMarius Wernig
Sep 2, 2018·Molecular Psychiatry·Cesar GonzalezClaudio Soto
Oct 26, 2018·Neuron·Neal D Amin, Sergiu P Paşca
Nov 1, 2018·Trends in Molecular Medicine·Cleber A Trujillo, Alysson R Muotri
Nov 2, 2018·Nature Protocols·Sonja BergmannChoi-Fong Cho
Nov 18, 2018·Journal of Cellular Physiology·Rahul MittalVasanti M Jhaveri
Jan 9, 2019·Molecular Psychiatry·Yannis Gerakis, Claudio Hetz
Feb 26, 2019·Stem Cell Reports·Hongwon KimJongpil Kim
Mar 12, 2019·Current Pharmaceutical Design·Yasamin A JodatSu R Shin
Mar 21, 2019·Frontiers in Pediatrics·Annalisa M HartlaubMark E Hester
Apr 3, 2019·Nature Biotechnology·Gustav Y CederquistLorenz Studer
Apr 10, 2019·NPJ Parkinson's Disease·Lisa M SmitsJens C Schwamborn
Apr 18, 2019·Development·Xuyu QianGuo-Li Ming
May 31, 2019·Frontiers in Cell and Developmental Biology·Valentina Perrera, Graziano Martello
Jun 5, 2019·Cell Transplantation·Abraam M Yakoub, Mark Sadek

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Citations

Dec 10, 2020·BMC Veterinary Research·Rachel A ScarfoneThomas G Koch
Jun 23, 2021·Acta Biomaterialia·Seokyoung BangHong Nam Kim

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Methods Mentioned

BETA
Fluorescent Activate Cell-Sorting

Software Mentioned

BenevolentBio

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