Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells

Bioorganic & Medicinal Chemistry
Xin WeiXiao-Dong Luo

Abstract

Unlike reported bisindoles linked by single bond directly, alstoniasidines A (1) and B (2), from Alstonia scholaris featuring unprecedented skeleton with two indole moieties bridged by a sugar, represented a novel bisindole type having strictosamide-glucopyranose-picraline scaffold. Both compounds exhibited selective cytotoxicity against human glioma stem cells (GSCs) and induced caspase-3 dependent extrinsic apoptosis by increasing the expression of interleukin 1 (IL-1), tumor necrosis factor (TNF-α), and the cleaved caspase-3, while damaged the unlimited proliferation and self-renewal capacity of GSCs. This finding might provide new type of leads for the selective killing of human glioma stem cells.

Citations

Feb 26, 2019·Chemistry & Biodiversity·Li-Qiu QuanHong-Mei Li
Jan 15, 2021·Journal of Ethnopharmacology·Hai-Lian YuanXiao-Dong Luo
Oct 24, 2019·Journal of Natural Products·Joanne Soon-Yee YeapToh-Seok Kam

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