Unprocessed real-time imaging of vitreoretinal surgical maneuvers using a microscope-integrated spectral-domain optical coherence tomography system.

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Paul HahnCynthia A Toth

Abstract

We have recently developed a microscope-integrated spectral-domain optical coherence tomography (MIOCT) device towards intrasurgical cross-sectional imaging of surgical maneuvers. In this report, we explore the capability of MIOCT to acquire real-time video imaging of vitreoretinal surgical maneuvers without post-processing modifications. Standard 3-port vitrectomy was performed in human during scheduled surgery as well as in cadaveric porcine eyes. MIOCT imaging of human subjects was performed in healthy normal volunteers and intraoperatively at a normal pause immediately following surgical manipulations, under an Institutional Review Board-approved protocol, with informed consent from all subjects. Video MIOCT imaging of live surgical manipulations was performed in cadaveric porcine eyes by carefully aligning B-scans with instrument orientation and movement. Inverted imaging was performed by lengthening of the reference arm to a position beyond the choroid. Unprocessed MIOCT imaging was successfully obtained in healthy human volunteers and in human patients undergoing surgery, with visualization of post-surgical changes in unprocessed single B-scans. Real-time, unprocessed MIOCT video imaging was successfully obtained in cada...Continue Reading

Associated Clinical Trials

References

May 10, 2008·Journal of Biomedical Optics·Shuo HanChanghuei Yang
Jul 22, 2008·American Journal of Ophthalmology·Richard F SpaideMaria C Pozonni
Oct 14, 2008·American Journal of Ophthalmology·Adrienne W ScottCynthia A Toth
Feb 5, 2010·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Charles C WykoffDitte Hess
Apr 27, 2010·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Amitha DomalpallyRonald P Danis
Oct 23, 2010·Optics Letters·Yuankai K TaoJoseph A Izatt
Jan 29, 2011·Retina·Susanne BinderCarl Glittenberg
Feb 2, 2011·Investigative Ophthalmology & Visual Science·Justis P EhlersCynthia A Toth
Jul 28, 2011·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Paul HahnCynthia A Toth
Aug 13, 2011·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Lyndon B Lee, Sunil K Srivastava

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Citations

Jun 4, 2015·Photonics·Karen M Joos, Jin-Hui Shen
Mar 22, 2014·Lasers in Surgery and Medicine·Zhuoyan LiKaren M Joos
Jul 4, 2015·Indian Journal of Ophthalmology·Chaitra JayadevNaresh Kumar Yadav
Jul 17, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·David H W SteelKathryn White
Mar 16, 2017·Ophthalmic Surgery, Lasers & Imaging Retina·Anne RunkleJustis P Ehlers
Feb 27, 2016·Current Opinion in Ophthalmology·Mehnaz Khan, Justis P Ehlers
Jul 3, 2015·Biomedical Optics Express·Gyeong Woo CheonJin U Kang
Sep 7, 2013·Biomedical Optics Express·Karen M Joos, Jin-Hui Shen
Mar 18, 2015·Biomedical Optics Express·Haoran YuKaren M Joos
Jul 1, 2017·Biomedical Optics Express·Oscar M Carrasco-ZevallosJoseph A Izatt
Oct 28, 2017·European Journal of Ophthalmology·Christoph LeisserOliver Findl
May 28, 2016·Biomedical Optics Express·Christian ViehlandJoseph A Izatt
Nov 27, 2019·Klinische Monatsblätter für Augenheilkunde·Christoph LeisserOliver Findl
Apr 5, 2021·Advances in Therapy·Elan Z AhronovichKaren M Joos
Nov 12, 2018·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Christoph LeisserOliver Findl

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