Unraveling Apathy in Korsakoff Syndrome Patients Receiving Long-Term Care With and Without Cerebrovascular Comorbidity.

Alcoholism, Clinical and Experimental Research
Misha J OeyErik Oudman

Abstract

Korsakoff syndrome (KS) is a severe neuropsychiatric disorder caused by acute deficiency of vitamin B1 and concomitant alcoholism. Patients with KS are particularly vulnerable for cerebrovascular comorbidity. KS is characterized by cognitive and neuropsychiatric symptoms, one of which is apathy. Apathy is a pathological lack of goal-directed behaviors, goal-directed cognitions, and goal-directed emotions. Cerebrovascular accidents are known to carry a risk for developing apathy. Apathy has a dramatic effect on the autonomy and daily lives of patients suffering from this condition. We assessed general apathy and related subconstructs in fifteen patients with KS, fifteen patients with KS and cerebrovascular comorbidity who reside in a 24-hour care facility, and fifteen healthy controls. Compared with healthy controls, both KS patient groups showed higher levels of apathy as rated by a close informant. We found no difference between both KS patient groups and the healthy control group on the self-report section of the Pleasant Activities List, suggesting that motivation is still intact in KS patients. It is important to note a discrepancy was found between self-reporting and proxy reporting on this list. KS patients with cerebrova...Continue Reading

References

Feb 1, 1978·The American Journal of Psychiatry·R Abrams, M A Taylor
Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Aug 1, 1991·Psychiatry Research·R S MarinS Firinciogullari
Jan 1, 1990·The American Journal of Psychiatry·R S Marin
Jan 1, 1996·Neurology·M S MegaJ Gornbein
Aug 11, 1998·Rehabilitation Nursing : the Official Journal of the Association of Rehabilitation Nurses·B ResnickA Adelman
Jul 18, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·J LindeboomC Jonker
Jul 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·S E StarksteinR Mizrahi
Oct 7, 2005·Cerebral Cortex·Richard Levy, Bruno Dubois
Feb 3, 2006·Schizophrenia Bulletin·Raquel E GurRuben C Gur
Apr 15, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·P SockeelL Defebvre
Nov 11, 2006·Brain : a Journal of Neurology·Dawn BowersMichael Okun
Apr 17, 2007·Lancet Neurology·Gianpietro Sechi, Alessandro Serra
Apr 20, 2007·Journal of Advanced Nursing·Evridiki PapastavrouPanagiota Sourtzi
Sep 5, 2008·The American Journal on Addictions·Hendrik G RoozenJ J M Vingerhoets
Jan 20, 2009·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Michael D KopelmanE Jane Marshall
Feb 10, 2009·European Psychiatry : the Journal of the Association of European Psychiatrists·P RobertJ Byrne
Aug 14, 2009·Alcoholism, Clinical and Experimental Research·Ksenija MarinkovicGordon J Harris
Aug 19, 2010·International Psychogeriatrics·Adrienne WithallPerminder S Sachdev
Jan 21, 2012·Alzheimer Disease and Associated Disorders·Jennifer MerrileesBruce L Miller
Feb 23, 2013·Cerebrovascular Diseases·Lara CaeiroJoão Costa
Apr 11, 2013·The Clinical Neuropsychologist·Elizabeth E MacDougall, William E Mansbach
Oct 31, 2013·Journal of the American Association of Nurse Practitioners·Caitlin HildebrandChristine Bradway
Jan 1, 2009·International Journal of Psychiatry in Clinical Practice·Roos Van Oort, Roy P C Kessels
Jun 29, 2014·Psychiatry Research·Ratko Radakovic, Sharon Abrahams
Nov 7, 2014·Journal of Alzheimer's Disease : JAD·Virginie DauphinotPierre Krolak-Salmon
Dec 1, 2011·Acta Neuropsychiatrica·Joukje M OostermanRoy P C Kessels
Jun 7, 2015·Neuropsychology Review·Erik OudmanStefan Van der Stigchel
Oct 1, 2002·Acta Neuropsychiatrica·Jos I M EggerJan J L Derksen
Mar 29, 2016·International Journal of Geriatric Psychiatry·Rianne M van der LindeCarol Brayne
Apr 28, 2016·Journal of Neuroscience Research·Amandine JullienneJerome Badaut
Jul 1, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Krista L LanctôtEleenor H Abraham
Dec 12, 2017·Neuropsychiatric Disease and Treatment·Nicolaas Jm ArtsRoy Pc Kessels
Mar 22, 2020·Brain Research·Simone de Andrade Baião GonçalvesLeonardo Cruz de Souza
Nov 28, 2020·Journal of Neuropsychology·Erik OudmanAlbert Postma

❮ Previous
Next ❯

Citations

Jun 3, 2021·Journal of Clinical Medicine·Maud E G van DorstRoy P C Kessels

❮ Previous
Next ❯

Software Mentioned

SPSS Statistics
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
S Ramos-da-SilvaC E Bacchi
American Journal of Clinical Dermatology
Anna M CattelanSavina M L Aversa
Positively Aware : the Monthly Journal of the Test Positive Aware Network
International Journal of Cancer. Journal International Du Cancer
L KestensP L Gigase
© 2021 Meta ULC. All rights reserved