Unraveling human natural killer cell deficiency.

The Journal of Clinical Investigation
Jordan S Orange

Abstract

NK cells are a component of the innate immune system identified in animals as serving an essential role in antiviral immunity. Establishing their role in human health has been challenging, with the most direct insight coming from the study of NK cell-deficient individuals. However, NK cell deficiencies are rare, and more research is needed. In this issue of the JCI, two independent groups of researchers have simultaneously identified the genetic cause of a human NK cell deficiency as mutation in the MCM4 gene, encoding minichromosome maintenance complex component 4. These reports suggest a critical role for the minichromosome maintenance helicase complex in NK cells and NK cell-mediated host defense.

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Citations

Oct 12, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Bibiana Bielekova
Feb 5, 2013·The Journal of Allergy and Clinical Immunology·Nima ParvanehMary Ellen Conley
Nov 18, 2015·Cell and Tissue Research·Jianhong ZhangStephen J Lye
Jul 25, 2015·Current Opinion in Virology·Berislav LisnićStipan Jonjić
Sep 16, 2015·The Journal of Allergy and Clinical Immunology·Francisco A BonillaJames W Verbsky
May 31, 2015·The Journal of Allergy and Clinical Immunology·Suheir HannaAmos Etzioni
Sep 3, 2013·The Journal of Allergy and Clinical Immunology·Jordan S Orange
May 6, 2014·Frontiers in Immunology·William T NashMichael G Brown
Apr 18, 2018·Cold Spring Harbor Perspectives in Medicine·Bibiana Bielekova
May 21, 2019·Journal of Pediatric Hematology/oncology·Katarzyna PopkoIwona Malinowska
Feb 6, 2017·Frontiers in Immunology·Norberto Walter Zwirner, Andrea Ziblat
Jun 7, 2015·Journal of Leukocyte Biology·Michael G Brown, Loren D Erickson
Dec 21, 2016·Frontiers in Immunology·Emily M Mace, Jordan S Orange
Nov 29, 2016·The Journal of Clinical Investigation·Emily M MaceJordan S Orange
Nov 2, 2019·JCI Insight·Petro StarokadomskyyEzra Burstein
Mar 13, 2018·The Journal of Clinical Investigation·Kang YuDeborah N Burshtyn
Sep 27, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jessica PrinceMichael G Brown
Nov 27, 2020·International Journal of Molecular Sciences·Samantha BarnesBree Foley
Oct 28, 2020·Journal of Cellular and Molecular Medicine·Haoyong LiXianping Che

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