Unraveling molecular targets of bisphenol A and S in the thyroid gland

Environmental Science and Pollution Research International
Clemilson Berto-JúniorLeandro Miranda-Alves

Abstract

Bisphenol A (BPA) is a well-known endocrine disruptor with several effects on reproduction, development, and cancer incidence, and it is highly used in the plastic industry. Bisphenol S (BPS) was proposed as an alternative to BPA since it has a similar structure and can be used to manufacture the same products. Some reports show that BPA interferes with thyroid function, but little is known about the involvement of BPS in thyroid function or how these molecules could possibly modulate at the same time the principal genes involved in thyroid physiology. Thus, the aims of this work were to evaluate in silico the possible interactions of BPA and BPS with the thyroid transcription factors Pax 8 and TTF1 and to study the actions in vivo of these compounds in zebrafish thyroid gene expression. Adult zebrafish treated with BPA or BPS showed that sodium iodide symporter, thyroglobulin, and thyroperoxidase genes were negatively or positively regulated, depending on the dose of the exposure. Human Pax 8 alignment with zebrafish Pax 8 and Rattus norvegicus TTF1 alignment with zebrafish TTF1 displayed highly conserved regions in the DNA binding sites. Molecular docking revealed the in silico interactions between the protein targets Pax 8 a...Continue Reading

References

May 16, 1998·The Biochemical Journal·C EspositoD Civitareale
Jun 11, 1998·Endocrine Journal·F Kambe, H Seo
Dec 9, 1998·Journal of Molecular Endocrinology·D FabbroG Damante
Nov 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Kenji MoriyamaKazuwa Nakao
Sep 11, 2004·Molecular and Cellular Endocrinology·Daniel Christophe
Sep 1, 2007·Journal of Biosciences·Sunil K Panigrahi, Gautam R Desiraju
Dec 21, 2007·Biological Reviews of the Cambridge Philosophical Society·Rowena SpenceCarl Smith
Oct 10, 2008·Archives of Toxicology·Mihi YangKeun-Young Yoo
Jun 2, 2009·Molecular and Cellular Endocrinology·P PorazziL Persani
Jul 7, 2009·Reproductive Toxicology·Maria BondessonJan-Ake Gustafsson
Mar 23, 2010·Molecular and Cellular Endocrinology·Lucia Montanelli, Massimo Tonacchera
Apr 30, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Robert Gerlai
Jun 15, 2010·Behavioural Brain Research·Danielle L ChampagneMichael K Richardson
May 17, 2011·Pharmacology, Biochemistry, and Behavior·Daiane L GebauerDiogo R Lara
Jun 17, 2011·Environmental Research·Jenny L Carwile, Karin B Michels
Sep 9, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Thaddeus T SchugJerrold J Heindel
Sep 9, 2011·Environmental Health Perspectives·Claire PhilippatRémy Slama
Mar 16, 2012·Endocrine Reviews·Laura N VandenbergJohn Peterson Myers
Jul 18, 2012·Pediatrics·Nancy N MaserejianDavid C Bellinger
Sep 3, 2013·Reproductive Toxicology·Johanna R Rochester
Oct 29, 2013·Reviews of Environmental Contamination and Toxicology·Faustin Pascal Tsagué ManfoPremendu Prakash Mathur
Feb 25, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Anna Kjerstine RosenmaiAnne Marie Vinggaard
Mar 19, 2014·Environmental Toxicology and Pharmacology·Jaromir Michałowicz
Jan 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Cassandra D KinchDeborah M Kurrasch
Apr 9, 2015·Journal of Cancer Prevention·Oneyeol YangYoung Rok Seo
Jun 9, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S Ahmed, E Atlas
Feb 6, 2017·Molecular and Cellular Endocrinology·Denise P Carvalho, Corinne Dupuy
Feb 9, 2017·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Sangwoo LeeKyungho Choi

❮ Previous
Next ❯

Citations

Apr 11, 2019·International Journal of Molecular Sciences·Sergio JarqueJavier Terriente
Dec 31, 2019·Endocrinology and Metabolism·Min Joo Kim, Young Joo Park
Apr 17, 2020·International Journal of Environmental Research and Public Health·Francesca GoriniFabrizio Bianchi
Apr 13, 2021·Clinical Kidney Journal·Sebastian MasEmilio Gonzalez-Parra

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Endocrinology
Peter P A Smyth, Roisin M Dwyer
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Jian CaoFuguang Jiang
Journal of Molecular Endocrinology
D FabbroGiuseppe Damante
© 2022 Meta ULC. All rights reserved