Unraveling of Central Nervous System Disease Mechanisms Using CRISPR Genome Manipulation

Journal of Central Nervous System Disease
Aino Vesikansa

Abstract

The complex structure and highly variable gene expression profile of the brain makes it among the most challenging fields to study in both basic and translational biological research. Most of the brain diseases are multifactorial and despite the rapidly increasing genomic data, molecular pathways and causal links between genes and central nervous system (CNS) diseases are largely unknown. The advent of an easy and flexible CRISPR-Cas genome editing technology has rapidly revolutionized the field of functional genomics and opened unprecedented possibilities to dissect the mechanisms of CNS disease. CRISPR-Cas allows a plenitude of applications for both gene-focused and genome-wide approaches, ranging from original "gene scissors" making permanent modifications in the genome to the regulation of gene expression and epigenetics. CRISPR technology provides a unique opportunity to establish new cellular and animal models of CNS diseases and holds potential for breakthroughs in the CNS research and drug development.

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Citations

Apr 24, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Sudhanshu P RaikwarAsgar Zaheer
Oct 22, 2019·Journal of Child and Adolescent Psychopharmacology·Zoe A BarczykRoger T Mulder
Nov 16, 2019·Molecular Neurodegeneration·Raphaella W L SoGerold Schmitt-Ulms

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Methods Mentioned

BETA
transgenic
gene knockout
genetic modification
gene knockouts

Software Mentioned

SLENDR
CORRECT

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