Unraveling Particle Formation: From Single Droplet Drying to Spray Drying and Electrospraying

Pharmaceutics
Eline BoelGuy Van den Mooter

Abstract

Spray drying and electrospraying are well-established drying processes that already have proven their value in the pharmaceutical field. However, there is currently still a lack of knowledge on the fundamentals of the particle formation process, thereby hampering fast and cost-effective particle engineering. To get a better understanding of how functional particles are formed with respect to process and formulation parameters, it is indispensable to offer a comprehensive overview of critical aspects of the droplet drying and particle formation process. This review therefore closely relates single droplet drying to pharmaceutical applications. Although excellent reviews exist of the different aspects, there is, to the best of our knowledge, no single review that describes all steps that one should consider when trying to engineer a certain type of particle morphology. The findings presented in this article have strengthened the predictive value of single droplet drying for pharmaceutical drying applications like spray drying and electrospraying. Continuous follow-up of the particle formation process in single droplet drying experiments hence allows optimization of manufacturing processes and particle engineering approaches and a...Continue Reading

References

Dec 25, 1996·Journal of Colloid and Interface Science·K Tang, A Gomez
Mar 31, 1998·Journal of Pharmaceutical Sciences·Y F MaaS W Hsu
Jul 27, 1999·Journal of Microencapsulation·D F BainA Smith
May 5, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·C BerklandD W Pack
Jun 5, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fang Jing Wang, Chi Hwa Wang
Jul 23, 2004·Lab on a Chip·Alaa OmraneStaffan Nilsson
Sep 30, 2004·International Journal of Pharmaceutics·Janne RaulaEsko I Kauppinen
Dec 8, 2004·Pharmaceutical Development and Technology·Kristina MosénAnders Axelsson
Dec 21, 2004·Drug Development and Industrial Pharmacy·N ClarkeZ Ramtoola
Mar 29, 2005·Optics Letters·Maria Rosaria VetranoMichel Léon Riethmuller
Jul 30, 2005·Journal of Pharmaceutical Sciences·Jessica Elversson, Anna Millqvist-Fureby
Jul 13, 2006·The Journal of Physical Chemistry. a·Rebecca J Hopkins, Jonathan P Reid
Jul 18, 2006·Journal of Colloid and Interface Science·Jingwei XieChi-Hwa Wang
Oct 10, 2006·Physical Review Letters·Tohru OkuzonoMasao Doi
Sep 8, 2007·Journal of Pharmaceutical Sciences·David Lechuga-BallesterosMei-Chang Kuo
Nov 28, 2007·Pharmaceutical Research·Reinhard Vehring
Dec 15, 2007·Optics Letters·J P van BeeckM L Riethmuller
Jun 9, 2009·International Journal of Pharmaceutics·Eva WulstenGeoffrey Lee
Oct 24, 2009·Physical Chemistry Chemical Physics : PCCP·Christian HeinischCameron Tropea
Dec 22, 2009·Journal of Colloid and Interface Science·Begoña AlmeríaAlessandro Gomez
Jun 4, 2010·Journal of the Royal Society, Interface·M EnayatiM Edirisinghe
Jul 14, 2010·Journal of Pharmaceutical Sciences·Jared A BairdLynne S Taylor
Jul 20, 2010·International Journal of Pharmaceutics·Shaoling Zhang, Kohsaku Kawakami
May 6, 2011·Archives of Pharmacal Research·Kultida SongsurangNongnuj Muangsin
Jun 3, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·J BahadurG Goerigk
Jun 28, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Yan-Ying LeeJukka Rantanen
Jun 29, 2012·Chemical Society Reviews·Ulrich K KriegerJonathan P Reid
Jul 12, 2012·The Journal of Chemical Physics·Hidenori SuzukiMaki Tachikawa
Dec 20, 2012·Expert Review of Medical Devices·Leilei ZhangRonald X Xu
Feb 12, 2013·Colloids and Surfaces. B, Biointerfaces·Belal Al Zaitone, Alf Lamprecht
Jul 13, 2013·Journal of Colloid and Interface Science·Eszter Bodnár, Joan Rosell-Llompart
Dec 17, 2014·Pharmaceutical Research·Jari Pekka PajanderMingshi Yang
Feb 17, 2015·Molecular Pharmaceutics·Alberto BaldelliReinhard Vehring
Aug 15, 2015·The Journal of Pharmacy and Pharmacology·Duong Nhat NguyenGuy Van den Mooter
Dec 27, 2015·Advanced Drug Delivery Reviews·Abhishek Singh, Guy Van den Mooter
Jun 12, 2016·Journal of Pharmaceutical Sciences·Duong Nhat NguyenGuy Van den Mooter

❮ Previous
Next ❯

Citations

Aug 13, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Melissa EveraertsGuy Van den Mooter
Apr 17, 2021·International Journal of Pharmaceutics·Wei-Ren KeHak-Kim Chan
Mar 31, 2021·Annual Review of Chemical and Biomolecular Engineering·John M BaumannJoel D Wood
Jun 8, 2021·Current Opinion in Colloid & Interface Science·Majid Rezaei, Roland R Netz

❮ Previous
Next ❯

Methods Mentioned

BETA
light
light scattering
Raman scattering
Raman spectroscopy
Raman
nuclear magnetic resonance
scanning electron microscopy
X-ray
electron spectroscopy
differential scanning calorimetry

Software Mentioned

gSOLIDS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.