Unraveling the Amycolatopsis tucumanensis copper-resistome

Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
José Sebastián Dávila CostaMaría Julia Amoroso

Abstract

Heavy metal pollution is widespread causing serious ecological problems in many parts of the world; especially in developing countries where a budget for remediation technology is not affordable. Therefore, screening for microbes with high accumulation capacities and studying their stable resistance characteristics is advisable to define cost-effective any remediation strategies. Herein, the copper-resistome of the novel copper-resistant strain Amycolatopsis tucumanensis was studied using several approaches. Two dimensional gel electrophoresis revealed that proteins of the central metabolism, energy production, transcriptional regulators, two-component system, antioxidants and protective metabolites increased their abundance upon copper-stress conditions. Transcriptome analysis revealed that in presence of copper, superoxide dismutase, alkyl hydroperoxide reductase and mycothiol reductase genes were markedly induced in expression. The oxidative damage of protein and lipid from A. tucumanensis was negligible compared with that observed in the copper-sensitive strain Amycolatopsis eurytherma. Thus, we provide evidence that A. tucumamensis shows a high adaptation towards copper, the sum of which is proposed as the copper-resistome...Continue Reading

References

Jan 1, 1997·Folia Microbiologica·H Hustavová, D Havraneková
Sep 28, 1999·Trends in Microbiology·M N Alekshun, S B Levy
Apr 15, 2000·The Journal of Biological Chemistry·P J HillasP R Ortiz De Montellano
Aug 31, 2000·Annual Review of Biochemistry·A M StockP N Goudreau
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jun 28, 2003·FEMS Microbiology Reviews·Christopher Rensing, Gregor Grass
Sep 22, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Guqi WangFrank J Burczynski
Oct 20, 2006·Proteomics·Angel MantecaJesus Sanchez
Dec 6, 2006·Drug Metabolism Reviews·Lawrence M SayreXiaoxia Tang
Dec 12, 2007·Journal of Basic Microbiology·C S BenimeliM J Amoroso
Aug 15, 2008·Journal of Basic Microbiology·Virginia Helena AlbarracínCarlos Mauricio Abate
Aug 16, 2008·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Götz HaferburgIsabel Sattler
Dec 24, 2008·Biotechnology Advances·Jianlong Wang, Can Chen
Feb 24, 2009·Analytical Biochemistry·Chris J HamiltonAlexandra Bonner
May 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Lee Macomber, James A Imlay
Aug 5, 2009·International Journal of Systematic and Evolutionary Microbiology·Virginia Helena AlbarracínCarlos Mauricio Abate
Oct 24, 2009·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Jeyaraman JeyakanthanShigeyuki Yokoyama
Apr 1, 2010·Environmental Microbiology·Joseph LemireVasu D Appanna
Apr 28, 2010·Annual Review of Microbiology·Nicholas NoinajSusan K Buchanan
May 29, 2010·Protein Science : a Publication of the Protein Society·Kristina HellbergDavid A Bernlohr
Jul 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Anita Krisko, Miroslav Radman
Jul 19, 2011·Ecotoxicology and Environmental Safety·José Sebastián Dávila CostaCarlos Mauricio Abate
Oct 11, 2011·Metallomics : Integrated Biometal Science·Christopher L DupontChristopher Rensing
Nov 19, 2011·FEMS Microbiology Letters·Moira MadeoConor P O'Byrne
Nov 23, 2011·Antimicrobial Agents and Chemotherapy·Swantje ReissSusanne Engelmann
Jan 17, 2012·Applied and Environmental Microbiology·Robert HongNidhi Gadura
Feb 22, 2012·FEMS Microbiology Letters·Swapna Aravind GudipatyMegan M McEvoy

❮ Previous
Next ❯

Citations

Feb 22, 2014·World Journal of Microbiology & Biotechnology·José Sebastián Dávila Costa, María Julia Amoroso
Oct 28, 2016·World Journal of Microbiology & Biotechnology·Natalia BourguignonManuel Ferrer
Jan 6, 2018·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Darshan M Rudakiya
May 3, 2019·Applied Microbiology and Biotechnology·Pedro E SineliJosé Sebastián Dávila Costa
May 17, 2018·Applied Microbiology and Biotechnology·Florian MeyerAlexander Steinbüchel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Bioremediation (ASM)

Bioremediation is the treatment and removal of harmful pollutants or contaminants through the use of microorganisms. Discover the latest research here.