Unraveling the blood transcriptome after real-life exposure of Wistar-rats to PM2.5, PM1 and water-soluble metals in the ambient air

Toxicology Reports
Ilias S FrydasDimosthenis A Sarigiannis

Abstract

Exposure to particulate matter (PM) is one of the most important environmental issues in Europe with major health impact. Various sizes of PM are suspended in the atmosphere and contributes to ambient air pollution. The current study aimed to explore the differential gene expression in blood, and the effect on the respective biological signaling pathways in Wistar rats, after exposure to PM2.5 and PM1 ambient air particles for an eight-week period. A control group was included with animals breathing non-filtered atmospheric air. In parallel, filtered PM2.5 and PM1 was collected in separate samplers. The results after whole genome microarray analysis showed 23 differentially expressed genes (DEGs) between control and PM2.5 group. In addition, pairwise comparison between control and PM1 group displayed 5635 DEGs linked to 69 biological pathways involved in inflammatory response, cell cycle and carcinogenicity. The smaller the size of the inhaled particles, the more gene alterations are triggered compared to non-filtered air group. More specifically, in inflammation signaling procedures differentially regulated gene expression was shown for interleukin-4 (IL-4), IL-7, IL-1, IL-5, IL-9, IL-6 and IL-2. We have identified that RASGFR...Continue Reading

References

Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·N N SandersJ Demeester
Apr 9, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·C AtumaL Holm
Mar 7, 2002·JAMA : the Journal of the American Medical Association·C Arden PopeGeorge D Thurston
Dec 13, 2005·American Journal of Respiratory and Critical Care Medicine·Nicholas L MillsDavid E Newby
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Shun-Ichiro MatsumotoYasufumi Shigeyoshi
Nov 7, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C de HaarR Pieters
Apr 10, 2010·American Journal of Respiratory and Critical Care Medicine·Matthew J StricklandPaige E Tolbert
Apr 13, 2010·Journal of Environmental Monitoring : JEM·Fulvio AmatoNuria Cots
May 27, 2010·Epidemiology·Richard W AtkinsonBen Armstrong
Aug 13, 2011·The Science of the Total Environment·Ulrich FranckOlf Herbarth
Mar 20, 2013·BioMed Research International·Francesca FarinaPaola Palestini
May 22, 2013·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Julia Y LjubimovaKeith L Black
Jul 10, 2013·Environmental Toxicology and Pharmacology·Chunling XiaoRenqun Wang
Aug 15, 2013·Environmental Health Perspectives·Xia MengHaidong Kan
Aug 15, 2013·Journal of Applied Toxicology : JAT·Qingyu HuangHeqing Shen
Apr 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Shitao LiMartin E Dorf
Jul 6, 2014·The Science of the Total Environment·M ManousakasK Katsanou
Dec 30, 2014·Environmental Research·Dimosthenis Α SarigiannisMarianthi Kermenidou
Mar 6, 2015·International Journal of Environmental Research and Public Health·Mei ChungDoug Brugge
Jun 1, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yi Shi, Aimin Huang
Jun 18, 2015·The Science of the Total Environment·Constantini SamaraApostolos Kelessis
Nov 12, 2016·Environmental Research·Alexander M ZakharenkoKirill S Golokhvast
Jul 19, 2017·Annual Review of Virology·Mayumi K HollyJason G Smith
Jun 23, 2018·The Journal of Experimental Medicine·Shinya TanakaChen Dong
Jun 27, 2018·Frontiers in Immunology·Siwen WangJian Ma
Feb 4, 2019·Progress in Molecular Biology and Translational Science·Yaguang ZhaoJia-Da Li
May 28, 2019·Environment International·Alma Lorelei de JesusLidia Morawska
Jan 14, 2020·Environmental Science and Pollution Research International·Efthalia KogianniConstantini Samara

❮ Previous
Next ❯

Citations

Sep 3, 2021·Journal of Molecular Neuroscience : MN·Yingchu GuXiangdong Chen
Sep 14, 2021·Journal of the Air & Waste Management Association·Xiaoliang ZhaoGuiguo Jiang

❮ Previous
Next ❯

Methods Mentioned

BETA
light scattering
in vitro transcription
Feature Extraction
nucleotide exchange
ubiquitination

Software Mentioned

SPSS
SPSS Statistics
Origin
Genespring
WikiPathways
Gene Set Enrichment Analysis ( GSEA )
Feature Extraction

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.