Jul 26, 2018

Unraveling the Functional Role of NPF6 Transporters

Frontiers in Plant Science
Zhengyu Wen, Brent N Kaiser

Abstract

The nitrate transporter 1/peptide transporter (NPF) family represents a growing list of putative nitrate permeable transport proteins expressed within multiple cell types and tissues across a diverse range of plant species. Their designation as nitrate permeable and/or selective transporters is slowly being defined as more genes are characterized and their functional activities tested both in planta and in vitro. The most notable of the NPF family has been the Arabidopsis thaliana homolog, AtNPF6.3, previously known as AtNRT1.1 or CHL1. AtNPF6.3 has traditionally been characterized as a dual-affinity nitrate transporter contributing to root nitrate uptake in Arabidopsis. It has also been identified as a nitrate sensor which regulates the expression of high-affinity nitrate transport proteins NRT2s and lateral root development as a part of the primary nitrate response in plants. The sensor function of AtNPF6.3 has also been attributed to its auxin transport activity. Other homologs of AtNPF6.3 are now being described highlighting the variability in their functional capabilities (alternative substrates and kinetics) linking to structural aspects of the proteins. This review focusses on NPF6.3-like transport proteins and the knowl...Continue Reading

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Mentioned in this Paper

Lateral Root Development
Genes
Arabidopsis
NRT1.1 protein, Arabidopsis
Auxins
CHL1
Uptake
AtNRT2.1 protein, Arabidopsis
Ions
Smad3 Protein

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