Unraveling the Intoxicating and Therapeutic Effects of Cannabis Ingredients on Psychosis and Cognition.

Frontiers in Psychology
Marco ColizziSagnik Bhattacharyya

Abstract

Research evidence suggests a dose-response relationship for the association between cannabis use and risk of psychosis. Such relationship seems to reflect an increased risk of psychosis not only as a function of frequent cannabis use, but also of high-potency cannabis use in terms of concentration of Δ-9-tetrahydrocannabinol (Δ9-THC), its main psychoactive component. This finding would be in line with the evidence that Δ9-THC administration induces transient psychosis-like symptoms in otherwise healthy individuals. Conversely, low-potency varieties would be less harmful because of their lower amount of Δ9-THC and potential compresence of another cannabinoid, cannabidiol (CBD), which seems to mitigate Δ9-THC detrimental effects. A growing body of studies begins to suggest that CBD may have not only protective effects against the psychotomimetic effects of Δ9-THC but even therapeutic properties on its own, opening new prospects for the treatment of psychosis. Despite being more limited, evidence of the effects of cannabis on cognition seems to come to similar conclusions, with increasing Δ9-THC exposure being responsible for the cognitive impairments attributed to recreational cannabis use while CBD preventing such effects and, w...Continue Reading

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Citations

Jan 9, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Brandon GunasekeraSagnik Bhattacharyya
Feb 9, 2021·Frontiers in Pharmacology·Albert BatallaMatthijs G Bossong
Feb 11, 2021·Toxins·Zeinab BreijyehLaura Scrano
Nov 14, 2020·Brain Sciences·Marco Colizzi, Sagnik Bhattacharyya
Mar 8, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tonisha Kearney-Ramos, Margaret Haney
Aug 17, 2021·Journal of Clinical Pharmacology·Joshua D BrownAmie J Goodin

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Cannabis & Cognition

The effect of cannabis on cognitive functioning is being explored for short and long-term effects. Recent studies have shown conflicting results, with some showing no significant effects and others showing neuropsychological impairment. Discover the latest research on cannabis and cognition here.