Unraveling the Mechanisms of Cutaneous Graft-Versus-Host Disease

Frontiers in Immunology
Pedro Santos E SousaRonjon Chakraverty

Abstract

The skin is the most common target organ affected by graft-versus-host disease (GVHD), with severity and response to therapy representing important predictors of patient survival. Although many of the initiating events in GVHD pathogenesis have been defined, less is known about why treatment resistance occurs or why there is often a permanent failure to restore tissue homeostasis. Emerging data suggest that the unique immune microenvironment in the skin is responsible for defining location- and context-specific mechanisms of injury that are distinct from those involved in other target organs. In this review, we address recent advances in our understanding of GVHD biology in the skin and outline the new research themes that will ultimately enable design of precision therapies.

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Citations

Nov 24, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·A Szlauer-StefańskaS Giebel
Sep 15, 2018·Frontiers in Immunology·Grégory EhxFrédéric Baron
Feb 6, 2020·Therapeutic Advances in Hematology·Daniele ZamaRiccardo Masetti
Feb 27, 2020·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Ara ChoRobert Knobler
Mar 7, 2021·International Journal of Molecular Sciences·Ethan Strattan, Gerhard Carl Hildebrandt
Dec 14, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·M SchumacherS M Müller
Oct 6, 2020·International Journal of Women's Dermatology·Rachel SennettAmanda F Marsch

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