Unraveling the mystery of HLA-B27 association with human spondyloarthropathies using transgenic and knock out mice

Seminars in Immunology
S D KhareC S David

Abstract

Human spondyloarthropathies have a strong association with the presence of MHC class I allele, HLA-B27. Spondyloarthropathies occur predominantly in males and are usually triggered by an infection with an enterobacteria. Similar to human disease, experimental animals with HLA-B27 transgene also develop spontaneous inflammatory disease. In addition to HLA-B27, the role of environmental antigens has also been implicated in the animal models. How bacteria interact with HLA-B27 is not yet clearly understood. By breeding HLA-B27 transgenic mice with various transgenic and knock out mice, we investigated the immune mechanism in this inflammatory disease. In this review, we will summarize our recent findings and propose a hypothesis.

Citations

Apr 16, 2004·The American Journal of the Medical Sciences·Edward F RosloniecAndrew H Kang
Feb 10, 2000·Springer Seminars in Immunopathology·N A MitchisonB Müller
Jul 7, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·T M C PereiraS S Meyrelles
Jan 30, 2015·American Journal of Hypertension·Gisele S LinceviciusRuy R Campos
Dec 7, 2018·Frontiers in Immunology·Abdulla WatadDennis McGonagle

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

© 2022 Meta ULC. All rights reserved