Unraveling the role of high mobility group box protein 1 in severe trauma.

Critical Care : the Official Journal of the Critical Care Forum
Edward Abraham

Abstract

High mobility group box protein 1 (HMGB1) has been shown to participate in acute inflammatory reactions, including acute lung injury and sepsis. There is also evidence that circulating levels of HMGB1 are increased after severe trauma and are associated with clinically important outcome parameters, including mortality. Recent studies demonstrated that HMGB1 itself has little or no proinflammatory activity, but is able to potentiate inflammatory responses through binding to mediators, such as endotoxin or cytokines. Important questions are to determine the binding partners for HMGB1 in the setting of severe injury and whether inhibition of interactions of HMGB1 and associated molecules with the cell surface can affect outcome after trauma.

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Citations

Sep 6, 2012·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Chuanxin WuJianping Gong
Apr 25, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Carl I SchulmanHelen Vlassara
Feb 9, 2016·Diagnostics·Christin Pilzweger, Stefan Holdenrieder
Nov 10, 2010·Acta Anaesthesiologica Scandinavica·B LundelandP Vaagenes
Jul 11, 2012·Mediators of Inflammation·Stefanie HirsigerDaniel Rittirsch
Oct 1, 2016·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Jan MácaMichal Holub
Apr 27, 2017·The Indian Journal of Surgery·Sevgi Buyukbese SarsuÖzlem Gümüstekin Bulbul
Oct 20, 2020·The Journal of Trauma and Acute Care Surgery·Pieter de JagerGuy A Richards

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