Unraveling the roles of Atg4 proteases from autophagy modulation to targeted cancer therapy

Cancer Letters
Lan ZhangY Cheng

Abstract

Atg4 proteases are cysteine proteases, which are well known for their crucial roles in the lipidation and delipidation of LC3 during the autophagy process. At least four human Atg4 homologs have been reported according to their sequence homology to the yeast Saccharomyces cerevisiae (Sc) Atg4. Accumulating evidence has recently indicated that abnormal expression levels of some human Atg4 proteins occur in several types of cancer cells, which may be closely related to tumor progression, tumor suppression and cancer therapy resistance. In this review, we focus on highlighting the pivotal roles of the human Atg4 proteases in the LC3 conjugation system and their major function in autophagy. Moreover, we further explore the roles of human Atg4 proteases as potential novel targets for cancer therapy. Taken together, these findings would shed light on elucidating the key roles of Atg4 proteases from autophagy modulation to targeted cancer therapy.

References

Nov 26, 2002·The Journal of Biological Chemistry·Guillermo MariñoCarlos López-Otín
Oct 11, 2003·Developmental Cell·Daniel J KlionskyYoshinori Ohsumi
Jun 1, 2004·Journal of Cell Science·Yukiko KabeyaTamotsu Yoshimori
Aug 25, 2004·The International Journal of Biochemistry & Cell Biology·Isei TanidaEiki Kominami
Sep 27, 2005·The Journal of Biological Chemistry·Kenji SugawaraFuyuhiko Inagaki
Oct 26, 2005·Cell Death and Differentiation·T Yorimitsu, D J Klionsky
Dec 6, 2005·Journal of Molecular Biology·Taichi KumanomidouTakashi Yamane
Sep 26, 2006·Nature Cell Biology·Shida YousefiHans-Uwe Simon
Apr 4, 2007·Autophagy·David T MaddenDale E Bredesen
Apr 20, 2007·The Journal of Biological Chemistry·Guillermo MariñoCarlos López-Otín
Nov 9, 2007·Apoptosis : an International Journal on Programmed Cell Death·Andrew Thorburn
Dec 7, 2007·Cell Metabolism·Cristina MammucariMarco Sandri
Feb 29, 2008·Nature·Noboru MizushimaDaniel J Klionsky
Mar 5, 2008·Cancer Research·Anja ApelAndreas Mayer
Sep 23, 2008·Cell Death and Differentiation·M C MaiuriG Kroemer
Oct 10, 2008·Cancer Letters·Dong-Hyung ChoJin Cheon Kim
Jan 27, 2009·Biochimica Et Biophysica Acta·Ning Chen, Vassiliki Karantza-Wadsworth
Apr 18, 2009·Biochimica Et Biophysica Acta·Eugenia MorselliGuido Kroemer
Aug 29, 2009·Autophagy·Virginie M S Betin, Jon D Lane
Jul 17, 2010·Veterinary Pathology·R ReadP Vogel
Dec 2, 2010·Autophagy·Joanna M NormanEdward T W Bampton
Jan 20, 2011·Journal of Biomolecular Screening·Chih-Wen ShuJohn C Reed
Aug 2, 2011·Annual Review of Cell and Developmental Biology·Noboru MizushimaYoshinori Ohsumi
Sep 15, 2011·The EMBO Journal·Lisa B FrankelAnders H Lund
Jan 14, 2012·Autophagy·Hitoshi NakatogawaYoshinori Ohsumi
May 25, 2012·Autophagy·Usha NairDaniel J Klionsky
Jun 2, 2012·Autophagy·Zhong-Qiu YuZhiping Xie
Jun 7, 2012·Toxicology and Applied Pharmacology·Yanchun LiEnlong Ma
Oct 9, 2012·The Journal of Biological Chemistry·Endalkachew Ashenafi AlemuTerje Johansen

❮ Previous
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Citations

Aug 27, 2016·ACS Medicinal Chemistry Letters·Zongxing QiuGuozhi Tang
Jul 20, 2016·Experimental and Molecular Pathology·M MasouminiaS W French
Jul 12, 2017·International Journal of Molecular Sciences·Svetlana Bortnik, Sharon M Gorski
Feb 9, 2018·Cellular and Molecular Life Sciences : CMLS·Jin ZhangBo Liu
Sep 14, 2017·The Journal of Antibiotics·Tatsuro Maruyama, Nobuo N Noda
May 15, 2019·Cancers·Yuanyuan FuMin Li
Jul 12, 2019·Journal of Experimental & Clinical Cancer Research : CR·Zhi-Peng WenXiao-Ping Chen
Aug 28, 2019·Cells·Alf Håkon Lystad, Anne Simonsen
Apr 4, 2017·Current Protocols in Protein Science·Jongchan WooSavithramma P Dinesh-Kumar
Jan 25, 2020·International Journal of Radiation Biology·Mohsen SisakhtZahra Khoshdel
Jun 11, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Melissa J AlldredStephen D Ginsberg
Aug 25, 2016·Oncotarget·Svetlana BortnikSharon M Gorski
Aug 1, 2020·The Journal of Biological Chemistry·Nathan NguyenThomas J Melia
Feb 14, 2018·International Journal of Oncology·Yanyan HanLianhong Li
Feb 18, 2017·Biomolecules·Samuel W FrenchBarbara A French
Oct 21, 2020·European Journal of Medicinal Chemistry·Gaoxia YangJie Liu
Sep 29, 2019·Microbial Pathogenesis·Nageswar Reddy ManchalaRajendra Pilankatta

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