Unraveling transformation of follicular lymphoma to diffuse large B-cell lymphoma

PloS One
Julia González-RincónMargarita Sánchez-Beato

Abstract

Follicular lymphoma (FL) is an indolent but largely incurable disease. Some patients suffer histological transformation to a more aggressive subtype with poorer prognosis. This study aimed to improve our understanding of the genetics underlying FL histological transformation, and to identify genetic drivers or promoters of the transformation by elucidating the differences between FL samples from patients who did and did not transform. We conducted targeted massive parallel sequencing of 22 pre-transformed FL/transformed diffuse large B-cell lymphoma pairs and 20 diagnostic samples from non-transformed FL patients. Additionally, 22 matched samples from 11 transformed FL patients (pre-transformed FL and diffuse large B-cell lymphoma) and 9 non-transformed FLs were studied for copy number variation using SNP arrays. We identified recurrently mutated genes that were enriched at transformation, most notably LRP1B, GNA13 and POU2AF1, which have roles in B-cell differentiation, GC architecture and migration. Mutations in POU2AF1 might be associated with lower levels of expression, were more frequent in transformed FLs, and seemed to be specific to transformed- compared with de novo-diffuse large B-cell lymphomas. Pre-transformed FLs c...Continue Reading

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Citations

Jan 3, 2020·International Journal of Molecular Medicine·Masuko Katoh, Masaru Katoh
Jul 18, 2020·Current Opinion in Oncology·Pierre Heimann, Laurent Dewispelaere
Jan 23, 2021·Scientific Reports·Lucía PedrosaMargarita Sánchez-Beato
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Mar 10, 2021·Pathology·Karthik A GanapathiParul Bhargava
Apr 4, 2021·Cancers·Adrián Mosquera OrgueiraJosé Luis Bello López
May 7, 2021·Annual Review of Biophysics·Ping ChenGuohong Li

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Datasets Mentioned

BETA
SRP121648

Methods Mentioned

BETA
biopsies
PCR
electrophoresis
biopsy
xenografts
ubiquitination

Software Mentioned

Integrative Genome viewer ( IGV )
iScan
Excel
Annovar
Illumina
GraphPad Prism7
GISTIC
SureDesign
Ion Reporter
STATA

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