Unraveling UCA1 lncRNA prognostic utility in urothelial bladder cancer

Carcinogenesis
Margaritis AvgerisAndreas Scorilas

Abstract

In the era of precision oncology, bladder cancer (BlCa) is characterized by generic patient management and lack of personalized prognosis and surveillance. Herein, we have studied the clinical significance of UCA1 lncRNA in improving patients' risk-stratification and prognosis. A screening cohort of 176 BlCa patients was used for UCA1 quantification. The Hedegaard et al. 2016 (n=476) and TCGA provisional (n=413) were analyzed as validation cohorts for NMIBC and MIBC, respectively. Patients' survival outcome was assessed using recurrence and progression for NMIBC, or death for MIBC as clinical endpoint events. Bootstrap analysis was performed for internal validation of Cox regression analysis, while the clinical benefit of disease prognosis was assessed by decision curve analysis. UCA1 was significantly overexpressed in bladder tumors compared to normal urothelium, which was confirmed only in the case of NMIBC. Interestingly, reduced expression of UCA1 was correlated with muscle-invasive disease, as well as with tumors of higher stage and grade. UCA1 loss was strongly associated with higher risk of short-term relapse (HR=1.974; p=0.032) and progression to invasive stages (HR=3.476; p=0.023) in NMIBC. In this regard, Hedegaard et...Continue Reading

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