Unraveling water's entropic mysteries: a unified view of nonpolar, polar, and ionic hydration

Accounts of Chemical Research
Dor Ben-Amotz, Robin Underwood

Abstract

[Figure: see text]. Most chemical processes on earth are intimately linked to the unique properties of water, relying on the versatility with which water interacts with molecules of varying sizes and polarities. These interactions determine everything from the structure and activity of proteins and living cells to the geological partitioning of water, oil, and minerals in the Earth's crust. The role of hydrophobic hydration in the formation of biological membranes and in protein folding, as well as the importance of electrostatic interactions in the hydration of polar and ionic species, are all well known. However, the underlying molecular mechanisms of hydration are often not as well understood. This Account summarizes and extends emerging understandings of these mechanisms to reveal a newly unified view of hydration and explain previously mystifying observations. For example, rare gas atoms (e.g., Ar) and alkali-halide ions (e.g., K+ and Cl-) have nearly identical experimental hydration entropies, despite the significant charge-induced reorganization of water molecules. Here, we explain how such previously mysterious observations may be understood as arising from Gibbs inequalities, which impose rigorous energetic upper and l...Continue Reading

References

Jan 1, 1986·Methods in Enzymology·L R Pratt, D Chandler
May 26, 1995·Science·B Honig, A Nicholls
Jan 18, 1996·Nature·J Israelachvili, H Wennerström
Jun 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sowmianarayanan RajamaniShekhar Garde
Nov 19, 2005·The Journal of Chemical Physics·Dor Ben-Amotz
May 4, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yng-Gwei Chen, John D Weeks
Jun 21, 2006·The Journal of Chemical Physics·A PaliwalM E Paulaitis
Jul 14, 2006·The Journal of Physical Chemistry. a·Pradip K Ghorai, Dmitry V Matyushov
Jul 21, 2006·The Journal of Physical Chemistry. B·Dor Ben-AmotzGeorge Stell
Oct 6, 2006·The Journal of Physical Chemistry. B·Dor Ben-Amotz, B Widom
Dec 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·B Widom, Dor Ben-Amotz
Feb 3, 2007·The Journal of Physical Chemistry. B·Jan WestergrenRoland Kjellander
Jan 1, 2006·Journal of Chemical Theory and Computation·David van der Spoel, Paul J van Maaren
Nov 1, 2007·Journal of Chemical Theory and Computation·Martin AlmlöfJohan Åqvist

❮ Previous
Next ❯

Citations

May 9, 2012·Journal of Computer-aided Molecular Design·Christopher R CorbeilPaul Labute
May 10, 2012·Accounts of Chemical Research·Isaac T S Li, Gilbert C Walker
Sep 26, 2012·Journal of the American Chemical Society·Aljaž Godec, Franci Merzel
Nov 26, 2010·The Journal of Physical Chemistry. a·Kan Xiong, Sanford A Asher
May 12, 2011·The Journal of Physical Chemistry. B·Shuangliang ZhaoJianzhong Wu
Jul 31, 2013·Physical Chemistry Chemical Physics : PCCP·Divya Nayar, Charusita Chakravarty
Jan 21, 2014·Physical Chemistry Chemical Physics : PCCP·Shada A AlsharifMiguel Jose Yacaman
Feb 15, 2014·The Journal of Physical Chemistry. B·N Galamba
Apr 4, 2014·Physical Chemistry Chemical Physics : PCCP·Divya Nayar, Charusita Chakravarty
Sep 26, 2009·The Journal of Chemical Physics·Manoj V AthawaleShekhar Garde
Mar 29, 2013·The Journal of Chemical Physics·Felix Sedlmeier, Roland R Netz
Aug 15, 2015·The Journal of Physical Chemistry. a·Anil KumarMichael D Sevilla
Dec 26, 2015·Journal of the American Chemical Society·Punidha SokkalingamBruce C Gibb
Mar 10, 2016·Biophysical Journal·Caitlin E Scott, Peter M Kekenes-Huskey
Nov 5, 2015·The Journal of Physical Chemistry. a·Kotchaphan KanjanaDavid M Bartels
Jun 18, 2009·Chemistry : a European Journal·Filipe Ferreira da SilvaPaul Scheier
May 16, 2009·Advances in Colloid and Interface Science·L Muthuselvi, Aruna Dhathathreyan
Apr 29, 2015·Journal of Medicinal Chemistry·Stefan GeschwindnerPatrik Johansson
Jul 15, 2015·Journal of the American Chemical Society·Lixu YangScott L Cockroft
Dec 2, 2011·The Journal of Chemical Physics·Robin Underwood, Dor Ben-Amotz
Apr 17, 2015·The Journal of Physical Chemistry. B·Corinne L D GibbBruce C Gibb
Apr 17, 2015·The Journal of Chemical Physics·Timir Hajari, Nico F A van der Vegt
May 2, 2016·The Journal of Chemical Physics·Claudio A Cerdeiriña, Pablo G Debenedetti
Apr 28, 2016·International Journal of Molecular Sciences·Kai Ma, Lin Zhao
May 25, 2016·Annual Review of Physical Chemistry·Dor Ben-Amotz
Jun 9, 2016·The Journal of Physical Chemistry. B·Maksim MisinMaxim V Fedorov
Jul 20, 2016·Journal of Computer-aided Molecular Design·Matthew R SullivanBruce C Gibb
Jul 22, 2016·Journal of Chemical Theory and Computation·Michael SchauperlKlaus R Liedl
Jan 31, 2013·The Journal of Physical Chemistry. B·N Galamba
Jul 17, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Fereshte TaherianNico F A van der Vegt
Jul 7, 2011·The Journal of Physical Chemistry. B·Thomas L Beck
Nov 15, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Iolanda FotticchiaConcetta Giancola
Sep 2, 2016·Journal of Chemical Theory and Computation·Hyung-Kyu LimHyungjun Kim
Nov 24, 2016·Physical Chemistry Chemical Physics : PCCP·Madhulika GuptaSanjoy Bandyopadhyay
Dec 20, 2017·Nature Chemistry·Paul S CremerDavid L Mobley
Oct 18, 2018·Physical Chemistry Chemical Physics : PCCP·Setare Mostajabi SarhangiDmitry V Matyushov
Nov 13, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Daniel R Martin, Dmitry V Matyushov
Aug 14, 2019·Nutrients·Isabel LorenzoJuan Carlos Yébenes
May 2, 2020·Electrophoresis·James P Barger, Patrick F Dillon
Jun 17, 2018·The Journal of Chemical Physics·Christina KlinkhammerMartina Havenith

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.