Unravelling intra- and intersegmental neuronal connectivity between central pattern generating networks in a multi-legged locomotor system

PloS One
S. DaunNils Rosjat

Abstract

Animal walking results from a complex interplay of central pattern generating networks (CPGs), local sensory signals expressing position, velocity and forces generated in the legs, and coordinating signals between neighboring legs. In particular, the CPGs control the activity of motoneuron (MN) pools which drive the muscles of the individual legs and are thereby responsible for the generation of rhythmic leg movements. The rhythmic activity of the CPGs as well as their connectivity can be modified by the aforementioned sensory signals. However, the precise nature of the interaction between the CPGs and these sensory signals has remained generally largely unknown. Experimental methods aiming at finding out details of these interactions often apply cholinergic agonists such as pilocarpine in order to induce rhythmic activity in the CPGs. Using this general approach, we removed the influence of sensory signals and investigated the putative connections between CPGs controlling the upward/downward movement in the different legs of the stick insect. The experimental data, i.e. the measured MN activities, underwent connectivity analysis using Dynamic Causal Modelling (DCM). This method can uncover the underlying coupling structure and...Continue Reading

References

Jan 1, 1990·Trends in Neurosciences·H Cruse
Jan 1, 1988·Comparative Biochemistry and Physiology. A, Comparative Physiology·J SchmitzF Delcomyn
Oct 31, 1980·Science·F Delcomyn
Dec 1, 2001·Current Biology : CB·E Marder, D Bucher
Nov 5, 2004·Journal of Neurophysiology·Björn Ch LudwarJoachim Schmidt
Jul 17, 2007·NeuroImage·R J MoranK J Friston
Sep 25, 2007·Brain Research Reviews·Ansgar BüschgesJoachim Schmidt
Nov 13, 2008·Cognitive Neurodynamics·Stefan J KiebelKarl J Friston
Jul 7, 2009·Journal of Neuroscience Methods·W D PennyK Friston
Dec 18, 2010·Journal of Computational Neuroscience·Silvia Daun-Gruhn, Tibor Istvan Tóth
Jul 20, 2011·Biological cybernetics·Silvia Daun-Gruhn, Ansgar Büschges
Sep 14, 2012·The Journal of Experimental Biology·Martyna GrabowskaSilvia Daun-Gruhn
Sep 11, 2013·NeuroImage·L RigouxJ Daunizeau
Dec 7, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jennifer M WalzPaul Sajda
Jan 27, 2017·Frontiers in Neural Circuits·Daniel KnebelJan Rillich
Jul 21, 2017·Journal of Neurophysiology·Charalampos MantziarisAnsgar Büschges

❮ Previous
Next ❯

Citations

Nov 7, 2019·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Stefan Schöneich, Berthold Hedwig

❮ Previous
Next ❯

Software Mentioned

Python
DCM
kit learn
Pro
MatLab scripts
Meso
sci
Dynamic Causal Modelling ( DCM )
Spike2
Statistical Parametric Mapping SPM12

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.