Unravelling the complicated evolutionary and dissemination history of HIV-1M subtype A lineages

Virus Evolution
M TongoD P Martin

Abstract

Subtype A is one of the rare HIV-1 group M (HIV-1M) lineages that is both widely distributed throughout the world and persists at high frequencies in the Congo Basin (CB), the site where HIV-1M likely originated. This, together with its high degree of diversity suggests that subtype A is amongst the fittest HIV-1M lineages. Here we use a comprehensive set of published near full-length subtype A sequences and A-derived genome fragments from both circulating and unique recombinant forms (CRFs/URFs) to obtain some insights into how frequently these lineages have independently seeded HIV-1M sub-epidemics in different parts of the world. We do this by inferring when and where the major subtype A lineages and subtype A-derived CRFs originated. Following its origin in the CB during the 1940s, we track the diversification and recombination history of subtype A sequences before and during its dissemination throughout much of the world between the 1950s and 1970s. Collectively, the timings and numbers of detectable subtype A recombination and dissemination events, the present broad global distribution of the sub-epidemics that were seeded by these events, and the high prevalence of subtype A sequences within the regions where these sub-e...Continue Reading

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Citations

Apr 5, 2019·Current Opinion in HIV and AIDS·Lucie Abeler-DörnerUNKNOWN PANGEA consortium
Mar 23, 2019·Scientific Reports·Joanna Smoleń-DzirbaTomasz J Wąsik
Jul 26, 2019·Virus Evolution·John Palmer, Art F Y Poon
Jul 3, 2021·Viruses·Rayana Katylin Mendes Da SilvaMonick Lindenmeyer Guimarães
Dec 14, 2021·PloS One·Syed Hani AbidiSyed Ali

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