Apr 3, 2014

Regenerated Interneurons Integrate Into Locomotor Circuitry Following Spinal Cord Injury

BioRxiv : the Preprint Server for Biology
João AraújoRichard I Dorsky


Whereas humans and other adult mammals lack the ability to regain locomotor function after spinal cord injury, zebrafish are able to recover swimming behavior even after complete spinal cord transection. We have previously shown that zebrafish larvae regenerate lost neurons within 9 days post-injury (dpi), but the functional contribution of these neurons to motor recovery is unknown. Here we show that multiple interneuron subtypes known to play a role in locomotor circuitry are regenerated in injured spinal cord segments during the period of functional recovery. Further, we show that one subtype of newly-generated interneurons receives excitatory input and fires synchronously with motor output by 9 dpi. Taken together, our data show that regenerative neurogenesis in the zebrafish spinal cord produces interneurons with the physiological capacity to participate in the recovery of locomotor function.

  • References
  • Citations


  • We're still populating references for this paper, please check back later.
  • References
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Science of Morphology
Disassembly by Symbiont of Host Cuticle
Reproduction Spores
Ascomycota (fungus)
Spores, Fungal
Patient Discharge

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Related Papers

Journal of Visualized Experiments : JoVE
Lisa K Briona, Richard I Dorsky
Journal of Genetics and Genomics = Yi Chuan Xue Bao
Ping FangMelitta Schachner
Progress in Neurobiology
Katharine E Lewis, Judith S Eisen
© 2020 Meta ULC. All rights reserved