Apr 3, 2014

Regenerated Interneurons Integrate Into Locomotor Circuitry Following Spinal Cord Injury

BioRxiv : the Preprint Server for Biology
João AraújoRichard I Dorsky

Abstract

Whereas humans and other adult mammals lack the ability to regain locomotor function after spinal cord injury, zebrafish are able to recover swimming behavior even after complete spinal cord transection. We have previously shown that zebrafish larvae regenerate lost neurons within 9 days post-injury (dpi), but the functional contribution of these neurons to motor recovery is unknown. Here we show that multiple interneuron subtypes known to play a role in locomotor circuitry are regenerated in injured spinal cord segments during the period of functional recovery. Further, we show that one subtype of newly-generated interneurons receives excitatory input and fires synchronously with motor output by 9 dpi. Taken together, our data show that regenerative neurogenesis in the zebrafish spinal cord produces interneurons with the physiological capacity to participate in the recovery of locomotor function.

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Mentioned in this Paper

Ophiocordyceps
Hypocreales
Science of Morphology
Camponotus
Disassembly by Symbiont of Host Cuticle
Reproduction Spores
Ascomycota (fungus)
Spores, Fungal
Patient Discharge
Documented

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