Unravelling the interaction between the DRD2 and DRD4 genes, personality traits and concussion risk

BMJ Open Sport & Exercise Medicine
Shameemah AbrahamsMichael Posthumus

Abstract

Concussion occurs when biomechanical forces transmitted to the head result in neurological deficits. Personality may affect the balance between safe and dangerous play potentially influencing concussion risk. Dopamine receptor D2 (DRD2) and dopamine receptor D4 (DRD4) genetic polymorphisms were previously associated with personality traits. This case-control genetic association study investigated the associations of (1) DRD2 and DRD4 genotypes with concussion susceptibility and personality, (2) personality with concussion susceptibility and (3) the statistical model of genotype, personality and concussion susceptibility. In total, 138 non-concussed controls and 163 previously concussed cases were recruited from high school (n=135, junior), club and professional rugby teams (n=166, senior). Participants were genotyped for DRD2 rs12364283 (A>G), DRD2 rs1076560 (C>A) and DRD4 rs1800955 (T>C) genetic variants. Statistical analyses including structural equation modelling were performed using the R environment and STATA. The rs1800955 CC genotype (p=0.014) and inferred DRD2 (rs12364283-rs1076560)-DRD4 (rs1800955) A-C-C allele combination (p=0.019) were associated with decreased concussion susceptibility in juniors. The rs1800955 TT a...Continue Reading

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Citations

Jan 28, 2021·Sports·Mark R AntrobusAlun G Williams
Mar 4, 2021·Current Psychiatry Reports·Spencer W LiebelSteven P Broglio
Mar 9, 2021·Frontiers in Immunology·Laura N VerboonAndrew D Greenhalgh
Oct 6, 2020·Medicine and Science in Sports and Exercise·Stuart K KimGeoffrey D Abrams
Feb 20, 2021·Medicine and Science in Sports and Exercise·Stuart K KimGeoffrey D Abrams

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

R
StepOnePlus
SNPassoc
stats
haplo
STATA
ImPACT
Sports Concussion Assessment Tool

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