Unravelling the mystery of the 'minimum important difference' using practical outcome measures in chronic respiratory disease

Chronic Respiratory Disease
Linzy Houchen-Wolloff, Rachael A Evans

Abstract

It is important for clinicians and researchers to understand the effects of treatments on their patients, both at an individual and group level. In clinical studies, treatment effects are often reported as a change in the outcome measure supported by a measure of variability; for example, the mean change with 95% confidence intervals and a probability ( p) value to indicate the level of statistical significance. However, a statistically significant change may not indicate a clinically meaningful or important change for clinicians or patients to interpret. The minimum clinically important difference (MCID) or minimally important difference (MID) has therefore been developed to add clinical relevance or patient experience to the reporting of an outcome measure. In this article, we consider the concept of the MID using the example of practical outcome measures in patients with CRD. We describe the various ways in which an MID can be calculated via anchor- and distribution-based methods, looking at practical examples and considering the importance of understanding how an MID was derived when seeking to apply it to a particular situation. The terms MID and MCID are challenging and often used interchangeably. However, we propose all ...Continue Reading

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Citations

Apr 11, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Olga TheouKenneth Rockwood
Mar 25, 2021·Anesthesiology·Franco Laghi, Nicola Cacciani

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