Unravelling the potential of nitric acid as a surface modifier for improving the hemocompatibility of metallocene polyethylene for blood contacting devices

PeerJ
Muthu Vignesh VellayappanIda Idayu Muhamad

Abstract

Design of blood compatible surfaces is obligatory to minimize platelet surface interactions and improve the thromboresistance of foreign surfaces when they are utilized as biomaterials particularly for blood contacting devices. Pure metallocene polyethylene (mPE) and nitric acid (HNO3) treated mPE antithrombogenicity and hydrophilicity were investigated. The contact angle of the mPE treated with HNO3 decreased. Surface of mPE and HNO3 treated mPE investigated with FTIR revealed no major changes in its functional groups. 3D Hirox digital microscopy, SEM and AFM images show increased porosity and surface roughness. Blood coagulation assays prothrombin time (PT) and activated partial thromboplastin time (APTT) were delayed significantly (P < 0.05) for HNO3 treated mPE. Hemolysis assay and platelet adhesion of the treated surface resulted in the lysis of red blood cells and platelet adherence, respectively indicating improved hemocompatibility of HNO3 treated mPE. To determine that HNO3 does not deteriorate elastic modulus of mPE, the elastic modulus of mPE and HNO3 treated mPE was compared and the result shows no significant difference. Hence, the overall observation suggests that the novel HNO3 treated mPE may hold great promises...Continue Reading

References

Sep 7, 2005·Biomaterials·Leena Pravina AmarnathAnand Ramamurthi
Aug 12, 2009·Advances in Colloid and Interface Science·T T ChauA V Nguyen
Aug 10, 2010·Colloids and Surfaces. B, Biointerfaces·Guicai LiNan Huang
Aug 13, 2011·Journal of Materials Science. Materials in Medicine·Tingting ZhaoTao Zhang
Jul 11, 2013·BioMed Research International·Hemanth MohandasEko Supriyanto
Aug 15, 2013·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Catarina PereiraIrina Crina Anca Sandu
Jun 5, 2014·BioMed Research International·Saravana Kumar JaganathanManjeesh Kumar Asokan
Apr 22, 2015·International Journal of Nanomedicine·Muthu Vignesh VellayappanMustafa Yusof
May 20, 2015·Science and Technology of Advanced Materials·Muthu Vignesh VellayappanMustafa Yusof
Oct 1, 2012·Materials Science & Engineering. C, Materials for Biological Applications·N GomathiS Neogi

❮ Previous
Next ❯

Citations

Jul 20, 2017·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·K H ParkJ Ha

❮ Previous
Next ❯

Methods Mentioned

BETA
infrared spectroscopy
X-ray
AFM

Software Mentioned

SPIWin

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.