Unravelling the receptor binding property of egg drop syndrome virus (EDSV) from the crystal structure of EDSV fiber head

International Journal of Biological Macromolecules
Yapeng SongGaiping Zhang

Abstract

Egg drop syndrome virus (EDSV) is an avian adenovirus that causes markedly decrease in egg production, and in the quality of the eggs when it infects chickens. Until now, EDSV virus-cell interactions are poorly understood, and the cellular receptor is still unknown. In the present study, we determined the atomic structure of the fiber head of EDSV (residues 377-644) at 2.74 Å resolution. Structure comparison with the (chick embryo lethal orphan) CELO long fiber head and human adenovirus fiber heads reveals that the avian adenovirus may interact with the same attachment factor in a unique fashion. Based on the previous studies of CELO virus, we assumed that the chicken coxsackievirus and adenovirus receptor (CAR) may be the attachment factor. We then demonstrate that the chicken CAR serves as a cellular attachment factor for EDSV based on three lines of evidences. Taken together, the results presented here are helpful for further exploring the pathogenesis related to the interaction between EDSV and host cells, and may be used for vaccine development and intervention strategies against EDSV infection.

References

Feb 10, 2000·Experimental Cell Research·R P TomkoL Philipson
Dec 1, 1953·Proceedings of the Society for Experimental Biology and Medicine·W P ROWET G WARD
Dec 2, 2004·Acta Crystallographica. Section D, Biological Crystallography·Paul Emsley, Kevin Cowtan
Mar 22, 2005·American Journal of Respiratory Cell and Molecular Biology·Katherine J D A ExcoffonJoseph Zabner
Apr 12, 2005·Advanced Drug Delivery Reviews·Carolyn B Coyne, Jeffrey M Bergelson
Aug 22, 2006·Virus Research·Joshua J ShortAlexander Pereboev
Aug 19, 2007·The Journal of General Virology·Pablo Guardado-CalvoMark J van Raaij
Jun 1, 2000·Avian Pathology : Journal of the W.V.P.A·M Hess
Aug 1, 2007·Journal of Applied Crystallography·Airlie J McCoyRandy J Read
Dec 15, 2010·Nature Medicine·Hongjie WangAndré Lieber
Dec 3, 2013·Nature Reviews. Microbiology·Tanner S Miest, Roberto Cattaneo
Mar 5, 2016·International Review of Cell and Molecular Biology·Fabien LoustalotSara Salinas
Jan 1, 1997·Methods in Enzymology·Zbyszek Otwinowski, Wladek Minor
May 27, 2017·The International Journal of Biochemistry & Cell Biology·Elena Ortiz-ZapaterMaddy Parsons
Apr 21, 2018·Proceedings of the National Academy of Sciences of the United States of America·Annasara LenmanNiklas Arnberg
Jun 14, 2018·Frontiers in Microbiology·Xueping WangJingyu Wang

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Citations

Jun 3, 2021·International Journal of Molecular Sciences·José GallardoCarmen San Martín

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