Unravelling the regulatory mechanisms that modulate the MEP pathway in higher plants

Journal of Experimental Botany
Elizabeth CordobaP León

Abstract

The methyl-D-erythritol 4-phosphate pathway is responsible for the biosynthesis of a substantial number of natural compounds of biological and biotechnological importance. In recent years, this pathway has become an obvious target to develop new herbicides and antimicrobial drugs. In addition, the production of a variety of compounds of medical and agricultural interest may be possible through the genetic manipulation of this pathway. To this end, a complete understanding of the molecular mechanisms that regulate this pathway is of tremendous importance. Recent data have accumulated that show some of the multiple mechanisms that regulate the methyl-D-erythritol 4-phosphate pathway in plants. In this review we will describe some of these and discuss their implications. It has been demonstrated that 1-deoxy-D-xylulose-5-phosphate synthase (DXS), the first enzyme of this route, plays a major role in the overall regulation of the pathway. A small gene family codes for this enzyme in most of the plants which have been analysed so far, and the members of these gene families belong to different phylogenetic groups. Each of these genes exhibits a distinct expression pattern, suggesting unique functions. One of the most interesting regu...Continue Reading

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Citations

Jun 22, 2010·Archives of Biochemistry and Biophysics·Manuel Rodríguez-Concepción
Jun 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jane L WardMichael H Beale
Apr 23, 2011·Journal of Experimental Botany·Ulf-Ingo FlüggeMarkus Gierth
Jan 5, 2011·Journal of Experimental Botany·Elizabeth CordobaPatricia León
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