Unravelling the tumor-suppressive functions of FOXO proteins

Trends in Cell Biology
Tobias B Dansen, B M Th Burgering

Abstract

Members of the forkhead box O (FOXO) family of transcription factors have been postulated to be tumor suppressors because of their established roles in cell-cycle arrest, apoptosis, DNA-damage repair and scavenging of reactive oxygen species. Recently, several animal model studies have shown that the FOXO proteins are indeed tumor suppressors. Furthermore, FOXO proteins have recently been implicated in the negative regulation of signaling by the hypoxia-inducible factor 1 during vascular development, raising the possibility that the FOXO proteins suppress not only tumor formation but also tumor angiogenesis and, possibly, metastasis. Here, we discuss recent advances in the understanding of the roles of FOXO family members in tumor suppression.

References

Apr 3, 1992·Cell·G I EvanD C Hancock
Dec 2, 1993·Nature·C KenyonR Tabtiang
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·T KamijoC J Sherr
Mar 13, 1999·The Journal of Biological Chemistry·A C LeeT Finkel
Oct 29, 1999·Genes & Development·C M EischenJ L Cleveland
May 18, 2001·Nature·G I Evan, K H Vousden
Jan 5, 2002·The Journal of Biological Chemistry·Tracy Tzu-Ling TangLaurence A Lasky
Feb 2, 2002·Science·David LandoMurray L Whitelaw
Mar 9, 2002·Molecular and Cellular Biology·Geert J P L KopsBoudewijn M T Burgering
Sep 20, 2002·Nature·Geert J P L KopsBoudewijn M T Burgering
Jun 5, 2003·Nature Reviews. Cancer·Marcos Malumbres, Mariano Barbacid
Jul 12, 2003·Science·Diego H CastrillonRonald A DePinho
Feb 24, 1956·Science·O WARBURG
Feb 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Taisuke HosakaKaren C Arden
Feb 26, 2004·Cell·Maria Carla MottaLeonard Guarente
Apr 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Alexander EgleSuzanne Cory
Apr 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vidyalakshmi ChandramohanGail E Sonenshein
May 6, 2004·The Journal of Biological Chemistry·Armando van der HorstBoudewijn M T Burgering
Oct 20, 2004·International Journal of Oncology·Masuko Katoh, Masaru Katoh
Nov 13, 2004·The EMBO Journal·Marieke A G EssersBoudewijn M T Burgering
Nov 19, 2004·Nature·Scott W LoweGerard Evan
Dec 22, 2004·Cell Cycle·Han You, Tak W Mak
Jan 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Haojie HuangDonald J Tindall
Feb 5, 2005·Trends in Biochemical Sciences·Lars P van der Heide, Marten P Smidt
Apr 23, 2005·Journal of Natural Products·Frank C SchroederJon Clardy

❮ Previous
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Citations

Feb 11, 2014·Nature Chemical Biology·Sai Pradeep VelagapudiMatthew D Disney
Apr 23, 2013·Oncogene·M Roth, W Y Chen
Jan 1, 2010·Future Medicinal Chemistry·Darren D BrowningRui Wang
Dec 13, 2012·Biochimica Et Biophysica Acta·Haidar Akl, Geert Bultynck
Aug 30, 2014·Cell Death and Differentiation·M SalazarG Velasco
Jan 30, 2010·Molecular Biology of the Cell·Amrik SinghRoya Khosravi-Far
Feb 4, 2010·The Journal of Biological Chemistry·Tobias CzymaiMarc Schmidt
Aug 3, 2010·Antioxidants & Redox Signaling·Kelvin YenHeidi A Tissenbaum
Oct 2, 2012·World Journal of Biological Chemistry·Wolfgang Link
Jan 30, 2013·International Journal of Molecular Sciences·Claudia GiachinoValentina Turinetto
Feb 20, 2013·Journal of Cell Science·Victoria A RafalskiAnne Brunet
Mar 19, 2013·BMC Medical Genetics·Hongzhuan YinQi Su
Jul 24, 2012·Nature Cell Biology·Kristan E van der VosPaul J Coffer
Jul 16, 2010·Antioxidants & Redox Signaling·Peter L J de KeizerTobias B Dansen
Nov 19, 2010·Antioxidants & Redox Signaling·Tobias B Dansen
Jan 17, 2012·Cellular and Molecular Bioengineering·Roland KaunasKayla J Bayless
Oct 16, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Fabian Zanella, Amancio Carnero
Mar 16, 2013·Cell Biochemistry and Biophysics·Azadeh Meshkini, Razieh Yazdanparast
Sep 18, 2012·Antioxidants & Redox Signaling·Paraskevi Charitou, Boudewijn M T Burgering
Jun 11, 2016·Current Pharmacology Reports·Jun He, Bing-Hua Jiang
Jul 3, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Seda EkizogluNur Buyru
Oct 2, 2012·Cancer Letters·Masuko KatohMasaru Katoh
Aug 13, 2011·Current Opinion in Cell Biology·Nazif Alic, Linda Partridge
Apr 26, 2012·European Journal of Immunology·Lionel LuronIrina A Udalova
Jan 24, 2013·Molecular Systems Biology·Astrid EijkelenboomBoudewijn M T Burgering
Aug 24, 2010·Immunological Reviews·Fabienne MackayMargaret L Hibbs
Sep 15, 2011·The EMBO Journal·Kim Steen JensenPeter Staller

❮ Previous
Next ❯

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