Unreliability of putative fMRI biomarkers during emotional face processing

NeuroImage
C L NordJ P Roiser

Abstract

There is considerable need to develop tailored approaches to psychiatric treatment. Numerous researchers have proposed using functional magnetic resonance imaging (fMRI) biomarkers to predict therapeutic response, in particular by measuring task-evoked subgenual anterior cingulate (sgACC) and amygdala activation in mood and anxiety disorders. Translating this to the clinic relies on the assumption that blood-oxygen-level dependent (BOLD) responses in these regions are stable within individuals. To test this assumption, we scanned a group of 29 volunteers twice (mean test-retest interval=14.3 days) and calculated the within-subject reliability of the amplitude of the amygdalae and sgACC BOLD responses to emotional faces using three paradigms: emotion identification; emotion matching; and gender classification. We also calculated the reliability of activation in a control region, the right fusiform face area (FFA). All three tasks elicited robust group activations in the amygdalae and sgACC (which changed little on average over scanning sessions), but within-subject reliability was surprisingly low, despite excellent reliability in the control right FFA region. Our findings demonstrate low statistical reliability of two important...Continue Reading

Citations

Jan 26, 2018·Wiley Interdisciplinary Reviews. Cognitive Science·Stefan FrässleKlaas E Stephan
Sep 28, 2017·Journal of Cognitive Neuroscience·Clara R GrabitzDorothy V M Bishop
Aug 19, 2018·The International Journal of Eating Disorders·Tom HildebrandtRobyn Sysko
Feb 11, 2019·Brain and Behavior·Esther HeckendorfRens Huffmeijer
Aug 28, 2019·Nature Human Behaviour·Maël LebretonStefano Palminteri
Oct 28, 2019·Neuroreport·Alina O TeterevaOlga V Martynova
Apr 18, 2020·Social Cognitive and Affective Neuroscience·Peter J GianarosTimothy D Verstynen
May 1, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Camilla L NordJonathan P Roiser
Aug 29, 2020·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Liliana Szyszka-SommerfeldKrzysztof Woźniak
Apr 24, 2019·Brain Sciences·Camilla L NordJonathan P Roiser
May 22, 2020·Personality Neuroscience·Katherine E MacDuffieAhmad R Hariri
Apr 3, 2020·Proceedings of the National Academy of Sciences of the United States of America·Michelle AchterbergEveline A Crone
Nov 25, 2019·Neuroimaging Clinics of North America·Anouk SchranteeLiesbeth Reneman
Mar 13, 2021·Current Behavioral Neuroscience Reports·Camilla L Nord
Oct 15, 2020·The European Journal of Neuroscience·Madeline J FarberAhmad R Hariri
Nov 19, 2017·Journal of Affective Disorders·Trehani M FonsekaSidney H Kennedy
Aug 2, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Agnes NorburyAdriana Feder
Dec 7, 2021·Frontiers in Behavioral Neuroscience·Alexa HaegerVera Dinkelacker

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Methods Mentioned

BETA
cognitive behavioural therapy

Software Mentioned

NimStim
Matlab
SPM
Statistical
PickAtlas

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