PMID: 2424584Jul 15, 1986Paper

Unresectable and locally recurrent rectal cancer treated with radiotherapy or bilateral internal iliac artery infusion of 5-fluorouracil

Cancer
G CarlssonA Lunderquist

Abstract

Seventy-nine patients with histopathologically verified unresectable or locally recurrent rectal cancer were nonrandomly allocated to radiotherapy or regional intra-arterial infusion of 5-Fluorouracil (5-FU). Fifteen patients with unresectable and 32 with locally recurrent rectal cancer were subjected to radiotherapy. The absorbed dose was 30 Gy in patients with an unresectable tumor and 45 Gy in patients with locally recurrent rectal cancer. Six patients with unresectable and 26 with locally recurrent rectal cancer received bilateral internal iliac artery infusion of 5-FU in a median dose of 7.5 g. There was no difference in survival between the two methods of treatment. Resection of an initially unresectable tumor could be performed in 5 of 21 patients (4 after radiotherapy and 1 after chemotherapy). All except eight patients had pelvic or perineal pain before treatment. Forty of 43 (93%) patients reported pain relief after radiotherapy and 21 of 28 (75%) after infusion therapy. Ten nonresponders were subjected to alternative treatment (three to intra-arterial infusion and seven to radiotherapy). Five of these ten patients reported complete pain relief and five partial pain relief. After radiotherapy, no significant side effe...Continue Reading

References

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Citations

Aug 1, 1987·World Journal of Surgery·C HerfarthP Hohenberger
May 13, 2011·Cell Biochemistry and Biophysics·Y LiuJ Zhuang
Aug 20, 2003·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·H J WaneboA Levy
Nov 8, 2013·Acta Oncologica·Marte Grønlie CameronMarianne Grønlie Guren
Oct 1, 1995·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H KocaogluM Unal

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