Unresectable hepatic PEComa: a rare malignancy treated with stereotactic body radiation therapy (SBRT) followed by complete resection

Radiation Oncology
Simon KirsteThomas Brunner

Abstract

Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal tumors occurring in various anatomic regions. Although diagnostic criteria and treatment management are not established, current treatment options consist of surgery and chemotherapy including mTOR inhibitors. Stereotactic body radiation therapy (SBRT) is a non-invasive ablative treatment which has shown excellent control rates for more common types of unresectable liver tumors and metastases. In this report we present a rare case of PEComa of the liver that was treated by stereotactic radiotherapy followed by resection. Staging and evaluation of treatment response was done by FDG-PET/CT. This case highlights the potential of SBRT as a neoadjuvant treatment even for rare liver malignancies. It is the first case of liver PEComa treated by SBRT and resection. A 52-year-old woman presented at an external hospital with abdominal pressure and pain in the right upper abdominal quadrant. A CT scan showed a 700 cm3 liver lesion in segment IV. In repeated biopsy in July 2015 histopathological workup showed a pleomorphic epitheloid tumor with small to medium sized cells expressing vimentin and melan-A while being negative for cytokeratin establishing the diagnosis of PEC...Continue Reading

References

Sep 14, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·D FinkN F Hacker
Oct 2, 2007·World Journal of Gastroenterology : WJG·Song-Hua FangJi-Bo Hu
Jan 22, 2008·World Journal of Gastroenterology : WJG·Carlos Eduardo PaivaSilvia Regina Rogatto
Mar 7, 2009·Cirugía española·Belinda Sánchez PérezJulio Santoyo Santoyo
Jan 6, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew J WagnerRobert G Maki
Jan 29, 2011·BMC Surgery·Federico SelvaggiPaolo Innocenti
Mar 19, 2011·Japanese Journal of Clinical Oncology·Kohei ShitaraKei Muro
May 23, 2012·Abdominal Imaging·Jian-song JiJing-jing Song
Jun 14, 2012·Clinical Nuclear Medicine·Rodney D WellingR Edward Coleman
Jun 19, 2013·Journal of Cancer Research and Therapeutics·Susama PatraMohamed Rela
Jun 19, 2013·Internal Medicine·Dongmei Yu, Shaoshan Tang
Jul 13, 2013·BMJ Case Reports·Tan To CheungRonnie T P Poon
Oct 17, 2013·Journal of Magnetic Resonance Imaging : JMRI·Yanfeng ZhaoJing Liang
Feb 4, 2014·Case Reports in Medicine·Faseeh KhajaShanedelle Norford
Jun 3, 2014·BMC Medical Imaging·Soma KumasakaYoshito Tsushima
Jul 10, 2014·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·Indranil GhoshLopamudra Mishra
Jul 19, 2014·Diagnostic Pathology·Hassania AmeurtesseAfaf Amarti
Nov 26, 2014·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Hye Won OhJeong Hee Lee
May 9, 2015·World Journal of Gastroenterology : WJG·Toshiya MaebayashiMasahiko Sugitani
Jul 15, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·John J BisslerKlemens Budde
Feb 13, 2016·Abdominal Radiology·Catherine H PhillipsSree Harsha Tirumani

❮ Previous
Next ❯

Citations

Jun 7, 2019·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Pei NieGuangjie Yang
Apr 6, 2019·World Journal of Clinical Oncology·Daniela Cornelia LazărMărioara Cornianu

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.