Unrestraining genetic processes with a protein-DNA hinge

Molecular Cell
T TomonagaDavid Levens

Abstract

Genetic processes require direct interactions between proteins bound at nonadjacent cis elements. Because duplex DNA is rigid, either the protein-protein interactions are strong enough to deform the double helix or some feature of the intervening DNA must encourage juxtaposition of separated sites. For example, bent DNA can bring together only certain precisely positioned cis elements with the same helical phase. Interposing a DNA segment that both bends and twists easily to create a universal joint would provide an even more general mechanism to promote the association of separated sites regardless of position. A cis element of the human c-myc gene, known to be melted in vivo, and its associated single-strand DNA binding protein were examined and found to comprise just such a protein-DNA hinge.

References

Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·F Claverie-Martin, B Magasanik
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B Sauer, N Henderson
Mar 3, 1995·The Journal of Biological Chemistry·T Tomonaga, D Levens
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America· Goryshin IYuW S Reznikoff
Aug 1, 1994·Molecular and Cellular Biology·C Chang, J D Gralla
Mar 10, 1994·Nature·J D KahnD M Crothers
Jan 11, 1994·Biochemistry·A Sancar
May 1, 1996·Molecular and Cellular Biology·E F MichelottiD Levens
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·T Tomonaga, D Levens
Apr 10, 1997·Nature·M Ptashne, A Gann
Aug 28, 1997·Nature·E F MichelottiD Levens

❮ Previous
Next ❯

Citations

Jan 15, 2008·Nature Structural & Molecular Biology·Fedor KouzineDavid Levens
Oct 27, 2004·Nature Structural & Molecular Biology·Fedor KouzineDavid Levens
Apr 2, 1999·Nucleic Acids Research·V M MarathiasP H Bolton
Aug 23, 2000·Nucleic Acids Research·G L GalliaK Khalili
Sep 17, 2003·Genes & Development·Richard H CarterLucia B Rothman-Denes
Dec 12, 2001·Molecular and Cellular Biology·Oleg Denisenko, Karol Bomsztyk
Jan 12, 2012·Biochimica Et Biophysica Acta·Laura BaranelloFedor Kouzine
Dec 11, 2007·Journal of Molecular Biology·Oleg Denisenko, Karol Bomsztyk
Jun 29, 1999·Cold Spring Harbor Symposia on Quantitative Biology·L B Rothman-DenesK Kazmierczak
Mar 17, 2018·International Journal of Molecular Sciences·Camilla Björkegren, Laura Baranello
Oct 9, 2002·Oncogene·Jian-Ping YangFlossie Wong-Staal
Apr 21, 2001·Oncogene·W R Taylor, G R Stark
Jul 3, 1999·The Journal of Biological Chemistry·F AgouM Véron
May 17, 2011·Physical Biology·David Levens, Craig J Benham
Mar 15, 2000·Journal of Molecular Biology·E D Ross Maher LJ 3RD
Sep 30, 2021·Nature Communications·Jonathan M FoggLynn Zechiedrich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
T Tomonaga, David Levens
Proceedings of the National Academy of Sciences of the United States of America
Adam Siddiqui-JainLaurence H Hurley
© 2022 Meta ULC. All rights reserved